寻常型天疱疮,桥粒胶蛋白,斑菲素蛋白,乙酰胆碱受体,甲状腺过氧化物酶 ," /> 寻常型天疱疮,桥粒胶蛋白,斑菲素蛋白,乙酰胆碱受体,甲状腺过氧化物酶 ,"/> 非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制

中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (5): 324-327.doi: 10.12144/zgmfskin202105324

• 综述 • 上一篇    下一篇

非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制

谢志敏1,2,沈旭成1,2,戴向农1,2,李青青1,2,叶兴东1,2   

  1. 1广州市皮肤病防治所皮肤科，广州，510095；
    2广州医科大学皮肤病研究所皮肤科，广州，510095
  • 出版日期:2021-05-15 发布日期:2021-04-29
  • 通讯作者: 叶兴东，E-mail: yxingdong@qq.com

Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris

XIE Zhimin1,2, SHEN Xuchen1,2, DAI Xiangnong1,2, LI Qingqing1,2, YE Xingdong1,2   

  1. 1 Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China; 2 Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China
  • Online:2021-05-15 Published:2021-04-29
  • Contact: YE Xingdong, E-mail: yxingdong@qq.com

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摘要： 既往发现寻常型天疱疮（pemphigus vulgaris, PV）发病机制与桥粒芯糖蛋白1（desmoglein，Dsg1)和 Dsg3抗体有关，目前在PV患者中发现大量非Dsg自身免疫性抗体，包括桥粒胶蛋白1（desmocollin，Dsc1）和Dsc3、斑菲素蛋白1（plakophilin，PKP1）和PKP3、斑珠蛋白（plakoglobin，PG）、桥粒斑蛋白（desmoplakin，DP）、乙酰胆碱受体等。本文对非Dsg蛋白在PV发病机制中的作用进行了综述。

关键词: 寻常型天疱疮')">

寻常型天疱疮, 桥粒胶蛋白, 斑菲素蛋白, 乙酰胆碱受体, 甲状腺过氧化物酶

Abstract: The the pathogenesis of pemphigus vulgaris (PV) was associated with autoantibodies against desmosomal cadherin, desmoglein1 (Dsg1) and Dsg3 in previous studies, and now many non-Dsg autoantibodies were reported including desmocollin (Dsc) 1 and Dsc3, plakophilin (PKP) 1 and PKP3, plakoglobin (PG), desmoplakin (DP), acetylcholine receptor (AChR), secretory pathway Ca2+/Mn2+-ATPase isoform 1 (SPCA1), thyroid peroxidase (TPO) and mitochondrial protein. The non-Dsg autoantibodies associated with pathogenesis of PV were reviewed in this paper.

Key words: pemphigus vulgaris, desmocollin, plakophilin, acetylcholine receptor, thyroid peroxidase