中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (9): 585-587.doi: 10.12144/zgmfskin202109585

• 病例报告 • 上一篇    下一篇

生殖器丘疹样棘层松解性皮病一例

罗丹1,冯涛2,吕小岩3   

  1. 1蓬安县人民医院皮肤性病科，四川南充蓬安，637800；
    2四川省第二中医医院皮肤中西医结合科，四川成都，610000；
    3四川大学华西医院皮肤性病科，四川成都，610041
  • 出版日期:2021-09-15 发布日期:2021-08-05
  • 通讯作者: 吕小岩，E-mail: clazhou@126.com

Papular acantholytic dyskeratosis of genitalia: a case report

LUO Dan1, FENG Tao2, LYU Xiaoyan3   

  1. 1 Department of Dermatology, Peng'an People's Hospital, Peng'an 637800, China; 
    2 Department of Dermatology, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu 610000, China; 
    3 Department of Dermatology, West China Hospital of Sichuan University, Chengdu 610041, China
  • Online:2021-09-15 Published:2021-08-05
  • Contact: LYU Xiaoyan, E-mail: clazhou@126.com

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摘要： 报道1例生殖器丘疹样棘层松解性皮病。患者，男，30岁。2年前肛周出现灰白色丘疹，部分融合，伴瘙痒。实验室检查：HPV6阳性，醋酸白试验、梅毒螺旋体明胶凝集试验(TPPA)、HIV均阴性。皮损组织病理示：基底层上方棘层下方多处裂隙，可见棘层松解细胞，中等量淋巴细胞浸润。直接免疫荧光：IgG、IgM、IgA、C3阴性。予以0.03%他克莫司外用6个月后丘疹明显变平，瘙痒缓解。

关键词: 生殖器丘疹样棘层松解性皮病, 局灶性皮肤棘层松解角化不良, 女阴丘疹样棘层松解性角化不良

Abstract: A case of papuloid acantholysis of genitalia is reported. A 30-year-old male presented with gray white papules around the anus with partial fusion and pruritus for two years. Laboratory examination showed positive for HPV6 and negative for acetic acid white test, Treponema pallidum gelatin agglutination test (TPPA) and HIV. Histopathological examination showed cleft between the basal layer and the spinous layer with acantholytic dyskeratotic cells and lymphocyte infiltration. Direct immunofluorescence: IgG, IgM, IgA and C3 were negative. After 6 months of topical application of 0.03% tacrolimus, the papules subside and the itching was relieved.

Key words: popular acantholytic dyskeratosis of the vulvocrural areas, focal acantholytic dyskeratosis, papular acantholytic dyskeratosis of vulva