中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (5): 334-337.doi: 10.12144/zgmfskin202405334

• 临床研究 • 上一篇    下一篇

雄激素性脱发综合疗法疗效评价

刘婧1,陈军1,陈丽华2,肖燕标3,谭晓慧4,张国成5   

  1. 1 南京医科大学第四附属医院，江苏南京，210000；2 泰州市人民医院，江苏泰州，225300；3 赣州市皮肤病医院，江西赣州，341000；4 中江县人民医院，四川中江，618100；5 中国医学科学院皮肤病医院，江苏南京，210000
  • 出版日期:2024-05-15 发布日期:2024-04-19

Effect of comprehensive treatment of androgenic alopecia

LIU Jing1, CHEN Jun1, CHEN Lihua2, XIAO Yanbiao3, TAN Xiaohui4, ZHANG Guocheng5   

  1. 1 Fourth Nanjing Medical University Hospital, Nanjing 210000, China; 2 Taizhou People's Hospital, Taizhou 225300, China; 3 Ganzhou Hospital for Dermatology, Ganzhou 341000, China; 4 Zhongjiang County People's Hospital, Zhongjiang 618100, China; 5 Hospital of Dermatology, Chinese Academy of Medical Sciences, Nanjing 210000, China
  • Online:2024-05-15 Published:2024-04-19

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摘要： 目的：评价综合疗法治疗雄激素性脱发的临床效果。方法：将符合纳入标准的60例男性雄激素性脱发患者按就诊顺序随机分为对照组及治疗组，每组30例。对照组：患者口服1 mg非那雄胺片，每日一次；口服4 mg甲泼尼龙片，每日一次；口服100 mg盐酸多西环素片，每日一次；外用米诺地尔酊剂，每日两次。外用二硫化硒洗剂，每周两次。治疗组：在对照组的基础上，每月进行1次皮内注射，将得宝松与2%利多卡因注射液混合，选择9号针头，于脱发区进行多点皮内注射。1个月为1疗程，共计3个疗程。结果：治疗组有效率达到76.67%，优于对照组50.00%，两组患者头皮瘙痒、油腻、脱发、鳞屑评分均有明显下降，治疗组明显优于对照组。两组患者治疗期间未见明显不良反应。结论：综合治疗雄激素性脱发效果显著。

关键词: 雄性激素脱发, 多中心, 临床观察

Abstract: Objective: To access the clinical effect of combined therapy on androgenic alopecia. Methods: Sixty male patients with androgen alopecia were randomly divided into control group and treatment group. Patients in the control group were treated with finasteride tablets, 1 mg, methylprednisolone tablets 4 mg, doxycycline hydrochloride tablets 100 mg, twice daily, and minoxidil tincture twice daily, selenium disulfide lotion, twice a week. The patients in the treatment group were given additional intradermal injection of diprospan mixed with 2% lidocaine, once a month. 1 month was 1 course of treatment, and the patients were treated for a total of 3 courses. Results: The effective rate of the treatment group was 76.67% , which was higher than that of the control group (50.00%) . The scores of scalp itching, greasy, alopecia and scaly in the two groups were obviously decreased, and the treatment group was obviously better than the control group. No obvious adverse reaction was found in the two groups during the treatment. Conclusions: The multi-center study on comprehensive treatment of androgenic alopecia is effective.

Key words: androgen alopecia, multicentric, clinical observation