中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (2): 155-158.doi: 10.12144/zgmfskin202502155

• 综述 • 上一篇    

PADIs在毛囊周期和炎症性脱发中的作用机制研究进展

纪叙1,纪明开2   

  1. 1大连医科大学第一临床学院，辽宁大连，116044；2厦门医学院附属第二医院皮肤科，福建厦门，361021
  • 出版日期:2025-02-15 发布日期:2025-01-22

Update of PADIs in hair follicle cycle and inflammatory hair loss

JI Xu1, JI Mingkai2   

  1. 1 The First Affiliated Hospital of Dalian Medical University, Dalian 116044, China；2 The Department of Dermatology, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, China
  • Online:2025-02-15 Published:2025-01-22

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摘要： 肽基精氨酸脱亚胺酶(peptidyl arginine deiminases，PADIs)表达于毛囊干细胞谱系，介导精氨酸转化为瓜氨酸，影响毛囊周期，在毛囊干细胞激活、谱系鉴定和分化中具有重要功能。瓜氨酸驱动促炎回路，中性粒细胞浸润，募集并激活T淋巴细胞，导致毛囊变性脱发。因此，瓜氨酸化具有调节毛囊再生并可能导致炎症性脱发的作用。本文就PADIs在毛囊周期和炎症性脱发中作用机制的研究进展进行综述。

关键词: 肽基精氨酸脱亚胺酶, 毛囊周期, 瓜氨酸化, 炎症性脱发

Abstract: Peptidyl arginine deiminases (PADIs) are expressed in the hair follicle stem cell lineage and mediate the conversion of arginine to citrulline, affecting the hair follicle cycle. They play a crucial role in the activation, lineage identification, and differentiation of hair follicle stem cells. Citrulline drives pro-inflammatory circuits, neutrophil infiltration, recruitment, and activation of T lymphocytes, leading to hair follicle degeneration and alopecia. Therefore, citrullination has a role in regulating hair follicle regeneration and may cause inflammatory alopecia. This paper reviews the update of the mechanisms of action of PADIs in the hair follicle cycle and inflammatory alopecia.

Key words: peptidyl arginine deiminases, hair follicle cycle, citrullination, inflammatory hair loss