中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (5): 361-363.doi: 10.12144/zgmfskin202505361

• 病例报告 • 上一篇    下一篇

淋巴细胞变异型嗜酸性粒细胞增多症一例

李可涵1,杜松丽2,胡媛1   

  1. 1遂宁市中心医院皮肤科，四川遂宁， 629000; 2遂宁市中心医院病理科，四川遂宁， 629000
  • 出版日期:2025-05-15 发布日期:2025-05-15

Lymphocytic variant of hypereosinophilic syndrome: a case report

LI Kehan1, DU Songli2, HU Yuan1   

  1. 1 Department of Dermatology, Suining Central Hospital, Suining 629000, China; 2 Department of Pathology, Suining Central Hospital, Suining 629000, China
  • Online:2025-05-15 Published:2025-05-15

PDF (PC)

12

摘要： 淋巴细胞变异型嗜酸性粒细胞增多症是嗜酸性粒细胞增多症的一种罕见亚型。患者,男，69岁，躯干、四肢反复红斑丘疹伴瘙痒2年，加重1个月。入院检查外周血嗜酸性粒细胞明显增多，皮肤组织病理示真皮浅层嗜酸性粒细胞浸润，骨髓细胞学见骨髓有核细胞增生活跃，嗜酸性粒细胞占5.5%。骨髓流式检测到27.61%T淋巴细胞异常(CD4阳性CD8阴性)；基因检测位点:BCR/ABL、PDGFRa、PDFGRβ及FGFR1、PCM1/JAK2基因均为阴性。给予糖皮质激素、抗组胺及对症治疗后好转出院。

关键词: 嗜酸性粒细胞增多症, 淋巴细胞变异型

Abstract: Lymphocytic variant of hypereosinophilic syndrome is a rare subtype of hypereosinophilic syndrome. A 69-year-old male patient had repeated erythema papulae on trunk and limbs with pruritus for 2 years, and was admitted to hospital one month after aggravation. Peripheral blood eosinophils increased significantly. Skin histopathology showed eosinophil infiltration in the superficial dermis. Bone marrow cytology examination revealed active proliferation of nucleated cells in the bone marrow, with eosinophils accounting for 5.5%. Flow cytometry of the bone marrow detected 27.61% abnormal T lymphocytes (CD4 positive and CD8 negative). Gene detection sites of BCR/ABL, PDGFRα, PDGFRβ, FGFR1, and PCM1/JAK2 genes were all negative. After receiving glucocorticoid, antihistamine and supporting symptomatic treatment, the patient improved and was discharged.

Key words: hypereosinophilic syndrome, lymphocytic variant