斑秃,Th22,IL-22,IL-17


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,"/> alopecia areata,Th22,IL-22,IL-17 ,"/> <p class="MsoNormal"> Th22<span>细胞及其细胞因子在斑秃患者外周血中的表达</span>

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (3): 129-131.

• 论著 •    下一篇

Th22细胞及其细胞因子在斑秃患者外周血中的表达

邬松涛1  周英2  何平3  黄丽1  黄贵义4   

  1. 1常德市皮肤病性病防治所,湖南常德,415000

    2中南大学湘雅二医院皮肤性病科,湖南长沙,410000

    3常德市第一人民医院皮肤性病科,湖南常德,415000

    4南丰县皮肤病性病防治院,江西南丰,344500

  • 出版日期:2017-03-15 发布日期:2018-12-14
  • 通讯作者: 黄贵义， E-mail: hxfu6688@126.com

Peripheral blood levels of Th22 and its associated cytokines in the patients with alopecia areata

WU Songtao1, ZHOU Ying2, HE Ping3, HUANG Li1, HUANG Guiyi4   

  1. 1. Changde Institute of Dermatology and Venereology, Changde 415000, Hunan, China;

    2. Department of Dermatovenerology, the Second Xiangya Hospital of Central South University, Changsha 410000, China;

    3. Department of Dermatovenerology, the First People's Hospital of Changde,Changde 415000, Hunan, China;

    4. Nanfeng County Institute of Dermatology and Venereology, Nanfeng 344500, Jiangxi, China

  • Online:2017-03-15 Published:2018-12-14
  • Contact: HUANG Guiyi, E-mail: hxfu6688@126.com

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279

摘要：

目的：检测Th22及其细胞因子在斑秃患者外周血中的表达。方法：采用流式细胞仪检测38例斑秃患者及38例对照的Th22细胞水平，用酶联免疫吸附检测细胞因子IL-22、IL-17的水平。结果：斑秃患者外周血Th22、Th17、IL-17+IL-22+CD4+、IFN-γ+IL-22+CD4+T及血清IL-22、IL-17水平均高于正常对照组（P<0.05）；重型斑秃和活动期患者高于轻型斑秃患者和稳定期患者的表达（均P<0.05）。结论：Th22及其细胞因子在斑秃患者中表达升高。

ont-fam?Cl?< 008hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:10.5000pt;mso-font-kerning:1.0000pt;" >4. Nanfeng County Institute of Dermatology and Venereology, Nanfeng 344500, Jiangxi, China

关键词: 斑秃')">

斑秃, Th22, IL-22,
')">IL-17


Abstract:

Objective: To detect the Th22 and its associated cytokines in the patients with alopecia areata. Methods: The levels of Th22 and associated cytokines (IL-22 and IL-17) in 38 patients with alopecia areata and 38 healthy controls were detected by flow cytometry and ELISA. Results: The expression levels of Th22, Th17, IL-17+ IL-22+, CD4+, IFN-gamma+ IL-22+ CD4+ T, IL-22 and IL-17 in the parents were higher than those in controls (P<0.05) and all the cytokines mentioned above in the patients with severe alopecia areata were higher than those in the patients with mild alopecia areata (P<0.05). Conclusion: The levels of Th22 and cytokines in the patients with alopecia areata are increased.

?r?n>?< 008e="Calibri" >IL-17+IL-22+CD4+、IFN-γ+IL-22+CD4+T及血清IL-22、IL-17水平均高于正常对照组（P<0.05）；重型斑秃和活动期患者高于轻型斑秃患者和稳定期患者的表达（均P<0.05）。结论：Th22及其细胞因子在斑秃患者中表达升高。ont-fam?Cl?< 008hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:10.5000pt;mso-font-kerning:1.0000pt;" >4. Nanfeng County Institute of Dermatology and Venereology, Nanfeng 344500, Jiangxi, China

Key words: alopecia areata')">

alopecia areata, Th22, IL-22, IL-17