中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (2): 98-100.

• 短篇论著 • 上一篇    下一篇

复发性生殖器疱疹sHLA-G及外周血T淋巴细胞亚群和NK细胞的表达

黄 蓉 刘 剑 熊洪平 叶尚勉   

  1. 成都中医药大学第二附属医院皮肤科，成都，610041
  • 出版日期:2016-02-15 发布日期:2018-12-18
  • 通讯作者: 刘剑,Email: 409516734@qq.com
  • 基金资助:
    四川省教育厅重点科研项目（编号：11ZA067）

Expression of plasma sHLA-G, T lymphocyte subsets and NK cells in patients with recurrent genital herpes

HUANG Rong, LIU Jian, XIONG Hongping, YE Shangmian   

  1. Department of Dermatology, Second Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610041, China
  • Online:2016-02-15 Published:2018-12-18
  • Contact: LIU Jian, Email: 409516734@qq.com

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摘要： 目的：明确复发性生殖器疱疹（RGH）患者治疗前后外周血T淋巴细胞亚群和NK细胞及sHLA-G水平变化。方法：采用酶联免疫吸附法和流式细胞仪分别检测60例RGH患者治疗前后血浆sHLA-G水平及外周血T淋巴细胞亚群和NK细胞表达。结果： RGH患者血浆sHLA-G水平治疗前后分别为11.03±14.57 U/mL和0.41±0.45 U/mL，差异有统计学意义（P<0.05）； NK细胞治疗前后分别为15.01±5.89 % 和17.72±5.56 %，差异有统计学意义（P <0.05）。CD3+T细胞、CD4+T细胞、CD8+T细胞及CD4+/CD8+治疗前后差异无统计学意义（P>0.05）。结论：外周血sHLA-G及NK细胞表达可能与RGH患者病情发展有关。

关键词: 复发性生殖器疱疹, sHLA-G, T淋巴细胞亚群, NK细胞

Abstract: Objective: To determine the change of the level of T lymphocyte subsets, NK cells plasma and sHLA-G in the patients with recurrent genital herpes (RGH) before and after treatment. Methods: The level of plasma sHLA-G was detected by the enzyme linked immunosorbent assay and the levels of T lymphocyte subsets and NK cells were detected by the flow cytometry in 60 patients. Result: The level of NK cells in the patients before and after treatment was 15.01±5.89 % and 17.72±5.56 %, with a significant difference (P<0.05). The level of sHLA-G was 11.03±14.57 U/mL and 0.41±0.45 U/mL, with a significant difference (P<0.05). There was no significant difference in the levels of CD3+ cells, CD4+T cells, CD8+T cells and CD4+/CD8+ in the patients before and after treatment. Conclusion: sHLA-G and NK cells may be related to the development of RGH.

Key words: RGH, sHLA-G, T lymphocyte subsets, NK cells