白癜风,亚甲基四氢叶酸还原酶,活性 ," /> 白癜风,亚甲基四氢叶酸还原酶,活性 ,"/> vitiligo,MTHFR,activity ,"/> <p class="MsoNormal"> 血清中亚甲基四氢叶酸还原酶活性与白癜风临床特征相关性研究

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (4): 202-204.

• 论著 • 上一篇    下一篇

血清中亚甲基四氢叶酸还原酶活性与白癜风临床特征相关性研究

陈佳希  易秀莉  李春英  高天文   

  1. 第四军医大学西京皮肤医院，西安，710032

  • 出版日期:2017-04-15 发布日期:2018-12-19
  • 通讯作者: 高天文，E-mail: gaotw@fmmu.edu.cn

Correlation between serum MTHFR activity and clinical features of the patients with vitiligo

CHEN Jiaxi, YI Xiuli, LI Chunying, GAO Tianwen   

  1. Department of dermatology, Xijing Hospital, Fourth military medical university, Xi'an 710032,China

  • Online:2017-04-15 Published:2018-12-19
  • Contact: GAO Tianwen, E-mail: gaotw@fmmu.edu.cn

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摘要：

目的：明确白癜风患者血清中亚甲基四氢叶酸还原酶（MTHFR）活性与白癜风临床特征间的关系。方法：选择性别年龄相匹配的白癜风患者及健康对照各90例，采用ELISA法检测血清中MTHFR活性。结果：白癜风患者血清中MTHFR活性为(332.77±92.85)U/L,显著低于对照组的(403.66±96.56)U/L，(P<0.0001)。静止期、进展期及快速进展期患者血清中MTHFR活性呈逐级降低趋势。MTHFR活性在患者性别、家族史、病程等方面无显著差异。结论：白癜风患者血清中MTHFR活性降低可能与白癜风疾病发展相关

关键词: 白癜风')">

白癜风, 亚甲基四氢叶酸还原酶, 活性

Abstract:

Objective:To determine the correlation between the serum methylenetetrahydrofolate reductase (MTHFR) activity and clinical features of the patients with vitiligo.  Methods: The MTHFR activity was detected by enzyme-linked immunosorbent assay (ELISA) in 90 patients with vitiligo and 90 controls with matched age and sex. Results: The mean level of MTHFR was 332.77±92.85 U/L in vitiligo, which was lower than that in controls (403.66±96.56 U/L), (P<0.0001). The level of MTHFR activity in stable vitiligo, progressive vitiligo and rapid progressive vitiligo was decreased in a descending manner. There was no significant difference of MTHFR activity in sex, family history and duration of the disease. Conclusion: Reduction of MTHFR activity may be associated with the development of vitiligo

Key words: vitiligo')">

vitiligo, MTHFR, activity