中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (3): 186-188.

• 综述 • 上一篇    下一篇

颗粒溶素在某些皮肤病中的研究进展

邱小惠 纪 超 程 波   

  1. 福建医科大学附属第一医院皮肤科 350005
  • 出版日期:2016-03-15 发布日期:2018-12-19
  • 通讯作者: 程波,E-mail:chengbo630415@126.com

Update of granulysin in some skin diseases

QIU Xiaohui, JI Chao, CHENG Bo.   

  1. Department of Dermatology, The First Hospital of Fujian Medical University，Fuzhou 350005,China
  • Online:2016-03-15 Published:2018-12-19
  • Contact: Cheng Bo,E-mail:chengbo630415@126.com

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摘要： 颗粒溶素是一种溶细胞和促炎症分子，表达于活化的人类细胞毒T细胞（CTLs）和自然杀伤（NK）细胞，参与Stevens-Johnson综合征/中毒性坏死性表皮松解症（SJS/TEN）、银屑病、毛囊炎、扁平苔藓和病毒性水疱等多种皮肤病的发生发展，尤其在SJS/TEN发病过程中是引起角质形成细胞凋亡的重要诱导物。本文就颗粒溶素在皮肤病早期诊断、病情监测及治疗中的应用作一综述。

关键词: 颗粒溶素, 中毒性坏死性表皮松解症

Abstract: Granulysin, a cytolytic and proinflammatory molecule which is produced by activated human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells plays a significant role in the development of multiple skin diseases such as Stevens-Johnson syndrome/toxic epidermal necrosis (SJS/TEN)，psoriasis, folliculitis, lichen planus and viral vesicles, etc. Especially granulysin is a key mediator for disseminating keratinocyte apoptosis in SJS/TEN. Studies on application of granulysin in skin disease including early diagnosis, illness monitoring and treatment was reviewed in the paper.

Key words: granulysin, toxic epidermal necrosis