Abstract: Objective: To analyze the clinical features, laboratory examinations and treatment of the patients with generalized pustular psoriasis (GPP) to evaluate the therapeutic outcome. Methods: Clinical data of 146 episodes of 120 patients with GPP in our hospital were retrospectively analyzed. Results: ① In children with GPP (≤14 years old), infection (52.00%) was the main triggering factor. Infection (27.27%) and drugs (25.62%) mainly were the triggering factors in adults (>14 years old) with GPP. Out of adults patients, 30.30% having a history of psoriasis vulgaris (PV) were triggered by drugs, but 45.45% without history of PV had a history of infection. Majority of episodes in children with GPP occurred in summer (40.00%), but the majority of espisodes in adults with GPP occurred in spring (34.71%). ② Compared the patients with the history of PV, the average age of onset in the patients without a history of PV was younger, the durition of hospitalization and persistence of pustular lesions was longer. Patients with hypocalcemia were more likely to develop fever than the patients  without hypocalcemia. The total effective rate of acitretin and total paeony glucosides of  was 89.57%. Conclusion: The clinical characteristics in children and adults, in the patients with a PV history and without a PV history, hypocalcemia group and non-hypocalcemia group are different. Fever and hypocalcemia are associated with the severity of the disease. Acitretin is effective in the treatment of the patients with GPP.