hypotrichosis,mutation,molecular genetics ,"/> 常染色体显性遗传性少毛症分子遗传学研究进展

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (8): 502-505.

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常染色体显性遗传性少毛症分子遗传学研究进展

黄鹤群  汤华阳  孙良丹  陈梦云  徐明贵  许奕荟  许静凯  张学军   

  1. 安徽医科大学皮肤病研究所,合肥,230000
  • 出版日期:2017-08-15 发布日期:2018-12-05
  • 通讯作者: 张学军,E-mail:ayzxj@vip.sina.com

Update of autosomal dominant hereditary hypotrichosis

HUANG Hequn, TANG Huayang, SUN Liangdan, CHEN Mengyun, XU Minggui, XU Yihui, XU Jingkai, ZHANG Xuejun.   

  1. Institute of Dermatology, Anhui Medical University, Hefei 230000, China
  • Online:2017-08-15 Published:2018-12-05
  • Contact: ZHANG Xuejun, E-mail:ayzxj@vip.sina.com

摘要: 遗传性少毛症是一种表现为毛发永久性部分或完全缺失的单基因遗传性疾病,按遗传异质性分为常染色体显性遗传、常染色体隐性遗传、X连锁显性遗传、X连锁隐性遗传。本文重点介绍常染色体显性遗传性少毛症的各种亚型:遗传性单纯性头皮性少毛症(HSS)、遗传性单纯性少毛症(HHS)、Marie Unna型少毛症(MUHH)、常染色体显性羊毛状发(ADWH)、生长期毛发松动综合征(LAHS)等分子遗传学研究进展。

关键词: 少毛症, 突变位点, 子遗传

Abstract: Hereditary hypotrichosis is a single gene genetic disease and the manifestation is partial or total hair loss permanently. According to the hereditary model, hereditary hypotrichosis includes the autosomal dominant, autosomal recessive, X-linked dominant and X-linked recessive hereditary hypotrichosis. This article focuses on the update of autosomal dominant hereditary hair less, including various subtypes, hypotrichosis simplex of scalp, hereditary hypotrichosis simplex, marie Unna hereditary hypotrichosis, autosomal dominant woolly hair and loose anagen hair syndrome.

Key words: hypotrichosis')">

hypotrichosis, mutation, molecular genetics