Abstract: Pagetoid reticulosis is a rare cutaneous T-cell lymphoma with non-specific clinical manifestations and is easily misdiagnosed. This paper reports a case of a 39-year-old male patient presented with plaque and exudation on his right planta for one year. Pathological examination of the lesion showed large number of mononuclear cells migrated into the epidermis, and there was infiltration of a large number of mononuclear lymphoid cells and eosinophils in the superficial dermis. Immunohistochemical staining showed CD3, CD2, CD8 and other antibodies were positive, and about 60%-70% cells were positive for Ki-67 in the epidermis. Pathological examination of the right inguinal lymph node showed reactive proliferation of lymphoid tissue. The patient was treated with oral acitretin, recombinant human interferon-alpha1b injection and superficial X-rayradiotherapy, and achieved complete remission after 3 months of treatment.

Key words: pagetoid reticulosis