Abstract: Objective: To compare the results of serum specific IgE antibody  and autologous serum skin test (ASST) in the patients with chronic spontaneous urticaria (CSU), in order to define the clinical significance of ASST. Methods: The serum specific IgE antibody detection and autologous serum skin test (ASST) were conducted in 305 patients with CSU, and the positive rates of the two grougs were compared. Results: The positive rates of serum specific IgE antibody of mites combination (ermatophagoides pteronyssinus/dermatophagoides farinae) and ASST in 305 patients with CSU were 47.87% and 58.03%,respectively. The positive rates of serum specific IgE antibody of mites combination  in the ASST positive group and ASST negative group were 34.46% and 66.41%, respectively with statistical significance (P<0.05). There was a negative correlation between the positive  of ASST and the serum specific IgE antibody of mites combination, house dust, dog, soybeans, and shrimp, with significant differences (P<0.05). Conclusion: Some serum specific IgE antibodies of common allergens in CSU patients are negatively correlated with the results of ASST. It is suggested that ASST should be included in the routine CSU clinical test and the serum specific IgE antibodied of the patients with ASST positive need not   be detected.

Key words: chronic spontaneous urticaria, serum specific IgE antibody, autologous serum skin test