中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (1): 13-16.doi: 10.12144/zgmfskin201901013

• 论著 • 上一篇    下一篇

36例肉芽肿性唇炎临床及病理分析

李不言1，2  卢宪梅2  孙勇虎2  周桂芝2  陈声利2  刘永霞2  陈学超2  王建文2  张福仁1,2
  

  1. 1山东中医药大学，济南，250355
    2山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2019-01-15 发布日期:2019-02-26
  • 通讯作者: 张福仁，E-mial: zhangfuren@hotmail.com

Clinical and pathological analysis of 36 cases with granulomatous chellitis

LI Buyan1，2, LU Xianmei2, SUN Yonghu2, ZHOU Guizhi2, CHEN Shengli2, LIU Yongxia2, CHEN Xuechao2, WANG Jianwen2, ZHANG Furen1，2   

  1. 1. Shandong University of Traditional Chinese Medicine，Jinan 250355，China;  2. Department of Dermatology，Shandong Provincial Institute of Dermatology and Venereology，Shandong Academy of Medical Sciences， Jinan 250022，China
  • Online:2019-01-15 Published:2019-02-26
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 对本院2013-2017年间经病理确诊的36例肉芽肿性唇炎的临床及病理资料进行回顾性分析，其中男11例，女25例，年龄23～77岁，平均52.97岁。皮损表现为持续性非凹陷性浸润性肿胀和红斑。36例患者的组织病理均有淋巴细胞及组织细胞浸润，其中浆细胞浸润24例，多核巨细胞浸润14例，嗜酸粒细胞浸润1例。治疗方式主要为病灶内注射糖皮质激素，口服糖皮质激素，羟氯喹，沙利度胺，雷公藤等。12例患者痊愈，9例患者好转，13例患者无效，2例病情加重。

Abstract: The clinical and pathological data of 36 patients with granulomatous cheilitis (GC) confirmed by biopsy in our hospital from 2013 to 2017 were analyzed. Of 36 patients, 11 were males and 25 were females. The age ranged from 23 to 77 years old, with an average of 52.97 years old. The lesions were characterized by persistent non-depressed invasive swelling and erythema. The biopsy showed the lymphocytes and histiocytes infiltration in 36 patients, plasma cells infiltration in 24 patients, multinucleated giant cell infiltration in 14 patients, eosinophil infiltration in one patient. The treatment included local injection of corticosteroid, oral administration of steroid, hydroxychloroquine, thalidomide, tripterygium and wilfordii. Twelve patients recovered completely, 9 patients relieved, 13 patients had no response to treatments, and 2 patients aggravated.