中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (4): 208-210.doi: 10.12144/zgmfskin201904208

• 论著 • 上一篇    下一篇

环氧合酶-2和磷酸化P38丝裂原活化蛋白激酶在扁平苔藓皮损中的表达

王娟1  白莉2  赵一锦1  鲍海平1  米希婷1   

  1. 1山西大同大学医学院,大同，037009
    2山西医科大学第一医院皮肤科,太原，030001
  • 出版日期:2019-04-15 发布日期:2019-05-17
  • 通讯作者: 王娟，E-mail：1055828575@qq.com

Expression of COX-2 and phosphorylated P38 mitogen-activated protein kinase in the lesions of lichen planus

WANG Juan1, BAI Li2, ZHAO Yijin1, BAO Haiping1, MI Xiting1   

  1. 1. Medical College of Shanxi Datong University,Datong 037009,China; 2. Department of Dermatology First Hospital,Shanxi Medical University, Taiyuan 030001, China 
  • Online:2019-04-15 Published:2019-05-17
  • Contact: WANG Juan, E-mail:1055828575@qq.com

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摘要： 目的：检测环氧合酶-2（COX-2）及其上游调控蛋白磷酸化P38丝裂原活化蛋白激酶（p-P38MAPK）在扁平苔藓皮损中的表达，探讨其在发病中的意义。方法：采用免疫组化技术检测20例扁平苔藓皮损标本中COX-2和p-P38MAPK的表达情况，20例正常皮肤组织作为对照。结果：20例扁平苔藓皮损标本中COX-2和p-P38MAPK的积分光密度值（IOD）分别为（8.46±1.79）×103和（11.54±2.85）×103，均明显高于对照组(3.14±2.35)×103和(6.26±3.12)×103，差别具有统计学意义（均P＜0.01），同时COX-2与p-P38MAPK的表达强度呈正相关（r=0.62，P＜0.01）。结论：扁平苔藓皮损中COX-2表达上调，可能与上游P38MAPK的活化有关，可能是引起扁平苔藓发病的环节之一。

关键词: 扁平苔藓, 环氧合酶-2, P38丝裂原活化蛋白激酶

Abstract: Objective: To detect the expression level of cyclooxygenase-2 (COX-2) and phosphorylated P38 mitogen-activated protein kinase (p-P38MAPK) in the lesions of lichen planus (LP) and to explore its role in the pathogenesis of LP. Methods: The expression level of COX-2 and p-P38MAPK in 20 lesions with LP and normal skin of 20 human controls were detected by immunohistochemical technology. Results: The IOD(integrated optical density) of COX-2 and p-P38MAPK in LP lesions were (8.46±1.79)×103 and (11.54±2.85)×103, which were both higher than those in the controls, (3.14±2.35)×103 and (6.26±3.12)×103, with significant differences (Ps＜0.01). There was a positive correlation between the expression level of COX-2 and p-P38MAPK in LP lesions (r=0.62,P＜0.01). Conclusion: The up-regulation of COX-2 expression may be correlated with the activation of upstream P38MAPK, which may be involved in the pathogenesis of lichen planus.

Key words: lichen planus, COX-2, P38 mitogen-activated protein kinase