中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (5): 284-286.doi: 10.12144/zgmfskin201905284

• 短篇论著 • 上一篇    下一篇

无水疱性类天疱疮二例并文献复习

王喆1,2  孙勇虎2  周桂芝2  张福仁1,2   

  1. 1山东大学附属省皮肤病医院，山东大学，山东济南，250022
    2山东省皮肤病性病防治研究所，山东省医学科学院，山东济南，250022
  • 出版日期:2019-05-15 发布日期:2019-06-03
  • 通讯作者: 张福仁，E-mail：zhangfuren@hotmail.com

Nonbullous pemphigoid: two cases report and literature review

WANG Zhe1,2, SUN Yonghu2, ZHOU Guizhi2, ZHANG Furen1,2   

  1. 1. Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan 250022, China; 2. Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2019-05-15 Published:2019-06-03
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 报道2例无水疱性类天疱疮并复习以往相关文献。例1，男，72岁，因全身皮肤红斑、丘疹伴瘙痒20天就诊，查体未见水疱。实验室检查血嗜酸性粒细胞升高，直接免疫荧光示基底膜带线状C3沉积，间接免疫荧光示抗基底膜带抗体阳性，抗BP230抗体、抗BP180抗体阳性。例2，女，79岁。因全身皮肤散在分布丘疹伴严重瘙痒20天就诊，查体见躯干四肢皮肤抓痕明显，未见水疱。血清中抗BP180抗体阳性。2例均诊断：无水疱性类天疱疮。予以小剂量糖皮质激素治疗后，控制病情，目前在随访中。

Abstract: Two cases with nonbullous pemphigoid is reported and relative literature is reviewed. One 72-years-old male presented with erythema and papules accompanied by pruritus all over the body for 20 days. On physical examination, there were no visible blisters. The level of eosinophils in blood was increased. Direct immunofluorescence showed a positive linear C3 deposition along the basal membrane band and indirect immunofluorescence showed anti-BP230 antibody and anti-BP180 antibody were  positive. Another 79-year-old female presented with papules all over the body with serve pruritus for 20 days. Physical examination showed obvious scratches without blisters. Eosinophil and anti-BP180 antibody were increased. Both cases were diagnosed as nonbullous pemphigoid. The disease was well controlled after using small dose glucocorticoid.