中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (7): 409-411.doi: 10.12144/zgmfskin201907409

• 论著 • 上一篇    下一篇

羟氯喹联合外用糖皮质激素治疗儿童泛发型环状肉芽肿一例并文献复习

张皓1,2  付希安2  刘永霞2  刘红2  张福仁2   

  1. 1滨州医学院，山东烟台，264003
    2山东省皮肤病医院&山东省皮肤病性病防治研究所，山东第一医科大学&山东省医学科学院, 山东济南，250022
  • 出版日期:2019-07-15 发布日期:2019-07-11
  • 通讯作者: 刘红，E-mail：hongyue2519@hotmail.com 张福仁，E-mail：zhangfuren@hotmail.com

Generalized annular granuloma in a child successfully treated with hydroxychloroquine combined with topical steroid: a case report and literature review

ZHANG Hao1，2, FU Xi'an2, LIU Yongxia2, LIU Hong2, ZHANG Furen2   

  1. 1. Binzhou Medical University, YanTai,Shandong 264003, China; 2. Shandong Provinicial Hospital for Skin Disease & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2019-07-15 Published:2019-07-11
  • Contact: LIU Hong, E-mail: hongyue2519@hotmail.com ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 报道1例羟氯喹联合外用糖皮质激素治疗儿童泛发型环状肉芽肿并对相关文献进行复习。患儿，男，8岁。躯干、四肢泛发性环状斑片2个月。组织病理检查：真皮内见上皮样肉芽肿，中央胶原纤维变性、坏死，肉芽肿周围组织细胞、淋巴细胞浸润，胶原纤维增生，胶原间散在单一核细胞浸润。诊断：泛发型环状肉芽肿。给予硫酸羟氯喹片0.1 g/d口服，皮损外用复方丙酸氯倍他索软膏，1个月后复诊明显好转。继续治疗并随访。

关键词: 泛发型环状肉芽肿, 羟氯喹

Abstract: A case of Generalized annular granuloma in a child successfully treated with hydroxychloroquine combined with topical steroid was reported and relevant literature was reviewed. An eight years old boy presented with generalized annular plaques on the trunk and extremities for 2 months. Histopathological examination showed mild hyperplasia of epidermis, epithelioid granuloma in dermis, with degeneration and necrosis of central collagen fibers, infiltration of tissue cells and lymphocytes around granuloma, proliferation of collagen fibers, infiltration of mononuclear cells between collagen. The diagnosis of generalized annular granuloma was made. After oral administration of hydroxychloroquine sulfate tablet 0.1 g/d and topical compound clobetasol propionate ointment for one month, the lesions were significantly improved.

Key words: generalized granuloma annulare, hydroxychloroquine