中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (1): 32-34.doi: 10.12144/zgmfskin202001032

• 短篇论著 • 上一篇    下一篇

S-100阳性泛发性幼年黄色肉芽肿一例并文献复习

张晶1,晏洪波1,黄长征2   

  1. 1中国人民解放军中部战区总医院皮肤科，武汉，430072；
    2华中科技大学同济医学院附属协和医院皮肤科，武汉，430022
  • 出版日期:2020-01-15 发布日期:2020-03-17
  • 通讯作者: 黄长征,E-mail：hcz0501@126.com；晏洪波,E-mail：Hbyan2002@aliyun.com

Generalized juvenile xanthogranuloma with S-100 positive：a case report and literature review

ZHANG Jing1, YAN Hongbo1, HUANG Changzheng2   

  1. 1 Department of Dermatology, General Hospital of Central Theater Command, Chinese Peoples Liberation Army, Wuhan 430072, China; 
    2 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Online:2020-01-15 Published:2020-03-17
  • Contact: HUANG Changzheng, E-mail：hcz0501@126.com；YAN Hongbo, E-mail：Hbyan2002@aliyun.com

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摘要： 报道1例S-100阳性泛发性幼年黄色肉芽肿患儿并对相关文献进行复习。患儿，男，6个月，面部、躯干、四肢起疹3个月余。组织病理示：表皮基本正常，真皮内可见团块状结节性浸润，浸润细胞主要为泡沫样组织细胞，梭形组织样细胞，并可见Touton巨细胞。免疫组化：泡沫样组织细胞及梭形组织样细胞CD68(+)，S-100(+)，CD1a(-)，Langerin（-）；电镜检查示：未见Birbeck颗粒。诊断：泛发性黄色肉芽肿。

关键词: 泛发性黄色肉芽肿, S-100蛋白

Abstract: A 6-month-old male infant with generalized juvenile xanthogranuloma was reported and related literature was reviewed. The infant presented with a 3-month history of brown-yellow papules scattered on the face，trunk and extremities. Skin biopsy showed a dermal infiltrate of many histiocytes, foam cell and Touton giant cell, eosinophilic granulocytes and a small number of lymphocytes. Immunohistochemical examination of the lesions showed positive staining for CD68, S-100 and negative for CD1a and langerin antibodie．Birbeck granules was not found under electron microscope.  The diagnosis of generalized juvenile xanthogranuloma was made.

Key words: generalized xanthogranuloma, S-100 protein