中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (2): 80-82.doi: 10.12144/zgmfskin202002080

• 论著 • 上一篇    下一篇

口服普萘洛尔联合聚桂醇局部注射治疗婴幼儿血管瘤的疗效评价

卢国坚   

  1. 广州市番禺区慢性病防治站，广州，511400
  • 出版日期:2020-02-15 发布日期:2020-03-18

Assessment of oral propranolol combined with local injection of lauryl alcohol in the treatment of infantile hemangioma

LU Guojian   

  1. Chronic Disease Prevention and Control Hospital, Panyu, Guangzhou 511400, China
  • Online:2020-02-15 Published:2020-03-18

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摘要： 目的：评价普萘洛尔联合局部注射聚桂醇治疗婴幼儿血管瘤的临床疗效。
方法：收集2014-2018年我科就诊的婴幼儿血管瘤患者，分为口服普萘洛尔组和口服普萘洛尔联合聚桂醇局部注射治疗组，随访观察12个月。结果：共治疗婴幼儿血管瘤患者43例，其中口服普萘洛尔组21例，口服普萘洛尔联合聚桂醇局部注射治疗组22例。全部患儿随访观察12个月，瘤体均有不同程度缩小、颜色变浅。口服普萘洛尔组治疗时间(148±32)天，治愈率为61.9%；联合治疗组治疗时间为(62±24)天，治愈率为95.45%，两者间差异均有统计学意义（Ps＜0.05）。43例患儿中有4例在服口服普萘洛尔1小时后出现心率减慢，经观察3 h后自行恢复正常,35例患儿血糖轻微降低，降低幅度≤0.2 mmol/L，未给予特殊处理。22例联合聚桂醇局部注射治疗患儿，7例注射局部有少量渗血。结论：口服普萘洛尔联合局部注射聚桂醇治疗婴幼儿血管瘤较单用普萘洛尔治疗疗程缩短，临床疗效更佳。

关键词: 普萘洛尔, 聚桂醇, 婴幼儿血管瘤

Abstract: Objective: To assess the clinical effect of oral propranolol combined with local injection of lauryl alcohol in the treatment of infantile hemangioma. Methods: The patients with infantile hemangioma diagnosed in our hospital from 2014 to 2018 were collected. The patients were divided into oral propranolol group and oral propranolol combined with local injection of lauryl alcohol group. Results: Forty three children were collected, of them 21 were treated by oral propranolol and 22 were treated oral propranolol combined with local injection of lauryl alcohol. All the patients were followed up for 12 months. All the tumors treated became smaller and atrophic. The treatment time of combined treatment group and oral propranolol group were (62±24) days and (148±32) days. The cure rate was 95.45% and 61.9%, with a significant difference (Ps<0.05). Of 43 patients, 4 developed low heart rate within 1 hour after oral propranolol, and recovered within 3 hours. The blood glucose was slightly decreased in 35 children (0.2 mmol/L, with no special treatment). Twenty-two cases were treated with additional local injection of lauryl alcohol, of them 7 cases had small amount of bleeding. Conclusion: The treatment course of infantile hemangioma with oral propranolol combined with local injection of lauryl alcohol is shorter than oral propranolol alone.

Key words: propranolol, polyglycol, infantile hemangioma