中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (5): 259-261.doi: 10.12144/zgmfskin202005259

• 论著 • 上一篇    下一篇

大疱性系统性红斑狼疮临床资料分析

温志华,姚煦   

  1. 中国医学科学院皮肤病医院，南京，210042
  • 出版日期:2020-05-15 发布日期:2020-05-28
  • 通讯作者: 姚煦，E-mail:dryao＿xu@126.com

Clinical analysis of bullous systemic lupus erythematosus

WEN Zhihua, YAO Xu   

  1. Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing 210042, China
  • Online:2020-05-15 Published:2020-05-28
  • Contact: YAO Xu, E-mail: dryao＿xu@126.com

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摘要： 分析国内近20年发表的大疱性系统性红斑狼疮38篇文献，共57例，其中女47例，男10例，平均(26.6±11.8)岁；典型皮损为暗红色斑疹或正常皮肤上出现水疱大疱；常累及血液系统（64.9%）、肾脏（61.4%）及关节（57.9%）；ANA阳性率为100%、dsDNA阳性率为66.7%、Sm抗体阳性率为59.6%；89.1%患者症状得到控制，其中23.6%患者单用糖皮质激素有效，76.4%患者联用DDS或其他免疫抑制剂。

Abstract: Fifty-seven patients (47 females, 10 males) with bullous systemic lupus erythematosus in 38 reports were analyzed.  The average age was (26.6±11.8) years. The typical lesions were tense vesicles and bullae on both erythematous patches and normal skin. 64.9%, 61.4% and 40% patients had hematologic abnormalities, renal involvement and polyarthritis respectively. ANA, dsDNA and anti-Smantibodies were positive in 100%, 66.7%, 59.6% patients respectively. 89.1% patients achieved clinical improvements, of whom 23.6% treated with corticosteroid alone and 76.4% treated with corticosteroid and DDS or other immunosuppressants.