中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (5): 286-289.doi: 10.12144/zgmfskin202105286

• 论著 • 上一篇    下一篇

皮肤Rosai-Dorfman病一例并文献回顾性分析

郭笑1,2,刘永霞1,周桂芝1,杨青1,2   

  1. 1山东第一医科大学附属皮肤病医院（山东省皮肤病医院，山东省皮肤病性病防治研究所），济南，250022；

    2山东第一医科大学，济南，250000

  • 出版日期:2021-05-15 发布日期:2021-04-29
  • 通讯作者: 杨青，E-mail：yangqing79@126.com

Cutaneous Rosai-Dorfman disease: a case report and a retrospective analysis of the literature

GUO Xiao1，2, LIU Yongxia1, ZHOU Guizhi1, YANG Qing1，2   

  1. 1 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University, Jinan 250022, China; 2 Shandong First Medical University, Jinan 250000, China
  • Online:2021-05-15 Published:2021-04-29
  • Contact: YANG Qing, E-mail: yangqing79@126.com

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摘要： 目的：皮肤Rosai-Dorfman病(cutaneous Rosai-Dorfman disease，CRDD)是一种罕见的组织细胞增生性疾病，本文对1例患者资料进行报道，并对既往文献进行回顾性临床病理分析。方法：通过PubMed查询公开发表的英文文献，对该病的人口统计学信息、临床表现、病理特点及治疗等情况进行分析总结。结果：共检索到符合标准的183篇文献，其中包括371例患者资料。分析结果显示男女比例为1∶1.1，平均年龄为46岁，以东亚人(52.3%)最为常见。皮损主要表现为多发的结节、斑块、丘疹，常见于四肢（43.1%）、躯干（36.9%）及面部（27.2%）。该病诊断主要依靠组织病理及免疫组化检查。疾病通常呈慢性良性病程。结论：CRDD好发于东亚人群，具有一定的临床和组织病理学特点，皮肤科医生应该提高对该病的认识。

关键词: 皮肤型Rosai-Dorfman病, 临床病理分析

Abstract: Objective: Cutaneous Rosai-Dorfman disease (CRDD) is a rare histiocytosis. The purpose of this study was to characterize CRDD through a retrospective clinicopathological analysis of the literature and present a new case. Methods: A literature search was performed on PubMed and information analysis was performed, which included demographics, clinical characteristics, histology, immunohistochemistry and treatment. Results: There were 183 studies available for analysis that included 371 cases. The male: female ratio was 1∶1.1, and the average age was 46 years. The disease is more common in Eastern-Asians (52.3%). The most commonly affected skin regions were limbs(43.1%) trunk(36.9%) and face (27.2%) and most lesions were multiple nodules, plaques and papules. The diagnosis of the disease mainly depends on histopathology and immunohistochemistry. The disease shows an indolent and benign course. Conclusion: Cutaneous Rosai-Dorfman disease is more common in East Asian population and it has certain clinical and pathological features. Dermatologists should improve the understanding of the disease.

Key words: Cutaneous Rosai-Dorfman disease, clinicopathological analysis