中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (11): 716-718.doi: 10.12144/zgmfskin202111716

• 临床研究 • 上一篇    下一篇

阿达木单抗联合糖皮质激素治疗儿童Stevens-Johnson综合征一例并文献复习

臧箫,宋平平,朱慧英,杜东红,施仲香   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院，山东省皮肤病性病防治研究所），济南，250022
  • 出版日期:2021-11-15 发布日期:2021-09-15
  • 通讯作者: 杜东红，E-mail: dudh2010@126.com

Adalimumab combined with glucocorticoid in the treatment of one pediatric case of Stevens-Johnson syndrome and review of the literature

ZANG Xiao, SONG Pingping, ZHU Huiying, DU Donghong, SHI Zhongxiang   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Jinan 250022, China
  • Online:2021-11-15 Published:2021-09-15
  • Contact: DU Donghong, E-mail: dudh2010@126.com

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摘要： 报道阿达木单抗联合糖皮质激素成功治疗一例儿童Stevens-Johnson综合征，并进行文献复习。患者，女，6岁。全身散在红斑、水疱伴发热4天。入院后第一天开始给予甲泼尼龙40 mg/d、人免疫球蛋白（10 g/d×5）治疗，一周后皮损改善不明显，入院第7天、第14天分别给予阿达木单抗40 mg、20 mg治疗，皮损逐渐消退。

关键词: Stevens-Johnson综合征, 中毒性表皮坏死松解症, 阿达木单抗

Abstract: One pediatric patient with Stevens-Johnson syndrome successfully treated by adalimumab combined with glucocorticoids is reported and relevant literatures are reviewed. A 6-year-old girl with scattered erythema, blisters all over the body with fever for 4 days. She was treated with methylprednisolone 40mg, once daily for 7 days and human immunoglobulin 10g, once daily for 5 days. The skin lesions were not improved. The patient were treated with adalimumab 40mg and 20mg at day 7 and day 14 after admission, and the skin lesions gradually subsided. 

Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, adalimumab