中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (1): 34-36.doi: 10.12144/zgmfskin202201034

• 临床研究 • 上一篇    下一篇

阿达木单抗联合丙种球蛋白治疗HSV相关性慢性复发性多形红斑一例

王娜,刘红,吴卫志,张朝霞,周桂芝,施仲香,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2022-01-15 发布日期:2021-11-01
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

TNF-α antagonist combined with immunoglobulin in the treatment of herpes virus-related chronic relapsing erythema multiforme: a case report

WANG Na, LIU Hong, WU Weizhi, ZHANG Zhaoxia, ZHOU Guizhi, SHI Zhongxiang, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venerology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2022-01-15 Published:2021-11-01
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

PDF (PC)

283

摘要： 本文报道种球蛋白联合阿达木单抗治疗单纯疱疹病毒（HSV）相关的复发性多形红斑1例并复习相关文献。患儿，男，9岁。口唇反复糜烂、渗出15个月，全身反复红斑8个月。皮肤科查体：口唇糜烂，背部、四肢散在暗红色斑片，局部周边可见松弛水疱。病理检查符合多形红斑，单纯疱疹病毒I型IgG滴度444.72 RU/mL。诊断为单纯疱疹病毒感染相关多形红斑，给予伐昔洛韦抗病毒治疗的同时，给予阿达木单抗联合人免疫球蛋白治疗，2周后皮损消退，单纯疱疹病毒I型IgG滴度明显下降。

关键词: 多形红斑, 单纯疱疹病毒, 肿瘤坏死因子拮抗剂

Abstract: We report a case of herpes simplex virus-related chronic relapsing erythema multiforme (EM) treated with adalimumab and immunoglobulin and review the related literature. A 9-year-old boy presented with repeated lip erosions for 15 months, and erythema all over the body for 8 months. Dermatological examination showed lip erosion, scattered dark red patches on back and limbs, with loosing blisters on the local periphery. The featrue of biopsy was consistent with EM, and the herpes simplex virus type I IgG titer was 444.72 RU/mL. The diagnose of erythema multiforme induced by herpes simplex virus was made. The patient was treated with valaciclovir, adalimumab and immunoglobulin, and the lesions subside after treatment for 2 weeks, and herpes simplex virus type I IgG titer was decreased significantly.

Key words: erythema multiforme, herpes simplex virus, tumor necrotic antagonist