中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (3): 153-157.doi: 10.12144/zgmfskin202203153

• 论著 • 上一篇    下一篇

PD-1阻断剂所致皮肤不良反应分析及文献回顾

孙靓1,韩丹1,胡菊丽2,刘文丽1,周艳1,梁艳1,穆欣1,牟宽厚1   

  1. 1西安交通大学第一附属医院皮肤科，陕西西安，710061；
    2陕西省咸阳市旬邑县医院皮肤科，陕西旬邑，711300
  • 出版日期:2022-03-15 发布日期:2022-01-04
  • 通讯作者: 牟宽厚，E-mail: mkhn001@163.com

PD-1 blockade therapy induced skin irAEs: cases report and literature review

SUN Liang1, HAN Dan1, HU Juli2, LIU Wenli1, ZHOU Yan1, LIANG Yan1, MU Xin1, MU Kuanhou1   

  1. 1 Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China;
    2 Department of Dermatology, Xunyi County Hospital of Shaanxi Province, Xunyi 711300, China
  • Online:2022-03-15 Published:2022-01-04
  • Contact: MU Kuanhou, E-mail: mkhn001@163.com.

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摘要： 抗程序细胞死亡蛋白1及配体阻断剂为代表的免疫治疗在肿瘤治疗中取得了突破性的进展,皮肤不良反应是最常见的免疫相关不良反应（irAEs）。本文报道临床中诊治的一组免疫相关不良反应，共4例，分别为湿疹、多形红斑、TEN、嗜酸细胞增多性皮炎，并回顾分析在Pubmed数据库检索2015年至今发表的PD-1/PD-L1免疫治疗导致皮肤不良反应的病例报道，包括患者年龄、性别、致皮肤irAEs的药物、皮肤irAEs类型等。以期提高对肿瘤免疫治疗过程中皮肤不良反应的关注，及时救治危及生命的皮肤不良反应，帮助改善肿瘤患者生存质量和预后。

关键词: 肿瘤免疫治疗, 免疫检查点抑制剂, 皮肤免疫相关不良反应

Abstract: PD-1/PD-L1 blockade therapy is a representative immunotherapy that shows a major breakthrough in cancer therapy and dermatologic reactions are the most prevalent immune-related adverse events (irAEs). We reported 4 cases of different skin irAEs, including eczema, erythema multiforme, TEN, eosinophilic dermatitis. And the studies of dermatologic reactions induced by PD-1/PD-L1 blockade from Pubmed since 2015 were respectively analyzed, including sex, age, drug and lesion type, etc. In order to improve the attention of irAEs manifested as skin disease, to timely treat the patient with life-threatening adverse reactions, and to help improve the quality of life and prognosis of tumor patients.

Key words: cancer immune therapy, checkpoint inhibitors, irAEs manifested as skin disease