中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (4): 236-237.doi: 10.12144/zgmfskin202204236

• 病例报告 • 上一篇    下一篇

吡非尼酮致皮肤光毒性反应一例

李隽1,2,张理涛2   

  1. 1天津中医药大学，天津，301617;
    2天津市中医药研究院附属医院，天津，300120
  • 出版日期:2022-04-15 发布日期:2022-02-10
  • 通讯作者: 张理涛，E-mail: zhanglitao@medmail.com.cn

Skin phototoxicity induced by pirfenidone: a case report

LI Jun1,2, ZHANG Litao2   

  1. 1 Tianjin University of Traditional Chinese Medicin，Tianjin 301617，China;
    2 Department of Dermatology，Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital，Tianjin 300120，China
  • Online:2022-04-15 Published:2022-02-10
  • Contact: ZHANG Litao, E-mail: zhanglitao@medmail.com.cn

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摘要： 吡非尼酮是一种新的广谱抗炎及抗纤维化药物，尤其对治疗特发性肺纤维化具有非常好的效果。但同时也存在较大的毒副作用，如光过敏。本文报道1例肺纤维化患者服用吡非尼酮4周后出现严重光毒性反应，停用吡非尼酮并给予糖皮质激素治疗后，皮损逐渐消退。

关键词: 吡非尼酮, 光毒性反应, 糖皮质激素

Abstract: Pirfenidone is a new broad-spectrum anti-inflammatory and anti-fibrosis drug, which has a very good effect on idiopathic pulmonary fibrosis. But it also has more adverse reactions, such as photosensitivity. We report a case of pulmonary fibrosis with severe phototoxicity after 4 weeks of pirfenidone treatment in this paper. The skin lesions gradually subside after pirfenidone was discontinued and glucocorticoid was given.

Key words: pirfenidone, phototoxic reaction, glucocorticoids