中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (6): 388-390.doi: 10.12144/zgmfskin202206388

• 病例报告 • 上一篇    下一篇

大疱性Sweet综合征合并克罗恩病一例

刘海东1,石秀艳1,闫东雷2   

  1. 1山东第一医科大学附属医院，聊城市人民医院皮肤科，山东聊城，252000；
    2山东第一医科大学附属医院，聊城市人民医院超声科，山东聊城，252000
  • 出版日期:2022-06-15 发布日期:2022-04-14
  • 通讯作者: 闫东雷，E-mail: ydl2010@139.com

Bullous Sweet's syndrome complicated with Crohn's disease：a case report

LIU Haidong1, SHI Xiuyan1, YAN Donglei2   

  1. 1 Derpartment of Dermatology, Liaocheng People's Hospital and Clinical School of Shandong First Medical University, Liaocheng 252000, China;
    2 Derpartment of Ultrasound, Liaocheng People's Hospital and Clinical School of Shandong First Medical University, Liaocheng 252000, China
  • Online:2022-06-15 Published:2022-04-14
  • Contact: YAN Donglei, E-mail: ydl2010@139.com

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摘要： 患者，男，65岁。因腹泻1个月，全身红斑、大疱、血疱5天伴发热入院。皮肤组织病理示：表皮角化过度，局部表皮缺失，表皮下疱形成，真皮乳头高度水肿，真皮浅中层多数中性粒细胞浸润。结肠组织病理特征符合克罗恩病改变。结合临床及病理表现诊断为大疱性Sweet综合征合并克罗恩病。治疗：给予甲泼尼龙40 mg/d，发热逐渐消退，皮疹逐渐减轻。

关键词: Sweet综合征, 克罗恩病

Abstract: A 65-year-old man presented with diarrhea for one month and erythema, bullae, and blood bullae all over the body associated with fever for 5 days. The skin biopsy of erythematous plaque revealed epidermal hyperkeratosis, subepidermal blister, edema of dermal papilla, infiltration of neutrophilic granulocyte. Histopathology features of the colon was consistent with Crohn's disease. The diagnosis of bullous Sweet's syndrome complicated with Crohn's disease was made. The patient was treated with methylprednisolone 40mg, once a day and the lesions subsided gradually.

Key words: sweet syndrome, Crohn's disease