中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (12): 884-886.doi: 10.12144/zgmfskin202212884

• 病例报告 • 上一篇    下一篇

不规则毛霉致皮肤型毛霉病一例

李倩1,2,张勇2,尹斌2,陈涛1,2,涂媛3   

  1. 1遵义医科大学研究生院，贵州遵义，563000；2成都市第二人民医院皮肤科，四川成都，610017；3成都市第二人民医院病理科，四川成都，610017
  • 出版日期:2022-12-15 发布日期:2022-10-26

Cutaneous mucormycosis caused by Mucor irregularis: a case report

LI Qian1,2, ZHANG Yong2, YIN Bin2, CHEN Tao1,2, TU Yuan3   

  1. 1 Graduate School of Zunyi Medical University, Zunyi 563000, China; 2 Department of Dermatology, The Second People's Hospital of Chengdu, Chengdu 610017, China; 3 Department of Pathology, The Second People's Hospital of Chengdu, Chengdu 610017, China
  • Online:2022-12-15 Published:2022-10-26

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摘要： 患者，女，65岁。反复左上肢结节、斑块、流脓伴疼痛7年，累及右上肢1年。2型糖尿病病史3年。左手背皮损组织病理示表皮棘层肥厚伴角化不全，真皮全层多灶肉芽肿形成伴淋巴细胞、浆细胞浸润，胶原纤维变性，并累及皮下脂肪；真菌培养示白色绒毛状菌落生长，镜下表现为粗大、无分隔菌丝，可见圆形孢子囊；宏基因组测序示不规则毛霉。诊断为不规则毛霉致皮肤型毛霉病。

关键词: 不规则毛霉, 皮肤型毛霉病, 菌种鉴定

Abstract: A 65-year-old female presented with repeated nodules, plaques and pus on the left upper limb with pain for more than 7 years, and the right upper limb was involved for 1 year. The patient had a 3-year history of type 2 diabetes. Histopathology showed epidermal spinous hypertrophy with incomplete keratosis, full-layer dermal multi-focal granuloma with infiltration of lymphocytes and plasma cells, degeneration of collagen fibers and involvement of subcutaneous fat. The fungus culture showed white villous colonies. Under the microscope, the colonies appeared to be thick and unseparated mycelia with circular sporangia. Metagenomic examination revealed Mucor irregularis. The diagnosis of cutaneous mucormycosis caused by mucor irregularis was made.

Key words: Mucor irregularis, cutaneous mucormycosis, strain identification