中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (12): 898-899.doi: 10.12144/zgmfskin202212898

• 病例报告 • 上一篇    下一篇

类风湿关节炎合并淋巴水肿角皮病一例

方梦,刘永霞,卢宪梅,刘红   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2022-12-15 发布日期:2022-10-26

Rheumatoid arthritis complicated with lymphedema keratoderma: a case report

FANG Meng, LIU Yongxia, LU Xianmei, LIU Hong   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2022-12-15 Published:2022-10-26

PDF (PC)

102

摘要： 患者，女，56岁。右上肢肿胀10年，加重伴皮肤肥厚、变硬7年余，既往类风湿病史12年。皮肤科查体：右上肢肘部以下可见弥漫性非凹陷性水肿，皮肤肥厚、变硬，部分皮肤有褐色角化性斑块。皮肤组织病理检查：表皮轻度乳头瘤样增生，真皮浅层散在载色素细胞，胶原纤维增粗，胶原间及血管周围淋巴细胞、浆细胞、中性粒细胞浸润。诊断：类风湿关节炎合并淋巴水肿角皮病。

关键词: 淋巴水肿角皮病, 类风湿关节炎, 滑膜增生

Abstract: A 56-year-old female presented with swelling on the right upper for 10 years, which was aggravated with skin hypertrophy and hardening for more than 7 years. She had a history of rheumatoid disease for 12 years. Physical examination showed diffuse nonpitting edema below the elbow on the right upper extremity, the skin was hypertrophied and hardened with some brown keratotic plaques. Pathological examination showed mild papilloma-like hyperplasia of the epidermis, scattered pigment cells in the superficial dermis, thickened collagen fibers, and infiltration of lymphocytes, plasma cells and neutrophils between collagens and perivascular. The diagnosis of rheumatoid arthritis combined with lymphedema keratoderma was made.

Key words: lymphedema keratoderma, rheumatoid arthritis, synovial hyperplasia