中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (8): 564-567.doi: 10.12144/zgmfskin202308564

• 论著 • 上一篇    下一篇

山东省麻风患者家庭内集聚性探究

孔瑶瑶,初同胜,刘殿昌,李聪聪,姚梦园,李洪达,靳传洋,袁召君,刘盟盟,刘健,槐鹏程,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2023-08-15 发布日期:2023-07-19

Research on agglomeration in leprosy families in Shandong Province

KONG Yaoyao, CHU Tongsheng, LIU Dianchang, LI Congcong, YAO Mengyuan, LI Hongda, JIN Chuanyang, YUAN Zhaojun, LIU Mengmeng, LIU Jian, HUAI Pengcheng, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-08-15 Published:2023-07-19

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摘要： 目的：通过更为细致的信息调查方法，掌握麻风康复者的家族史数据，了解有家族史的麻风康复者的流行病学特征。方法：以既往发现的2210例麻风康复者为调查对象。通过查阅原始病历、患者登记表，调查皮防工作者、乡医，入户随访等方式追踪家族史及临床信息。统计分析部分采用SPSS25.0进行单因素t检验和卡方检验。结果：纳入分析的麻风康复者的有效例数为1964例，男女性别比为3.9〖DK(〗∶〖DK)〗1；平均发病年龄(22.18±12.14)岁，平均确诊年龄(25.64±11.89)岁。临床分型以结核样型麻风（1026例，52.24%），瘤型麻风患者（725例，36.91%）为主。399例（20.32%）麻风康复者有家族史。女性（24.44%）麻风康复者有家族史的比例高于男性（19.26%）、多菌型（27.77%）麻风康复者有家族史的比例高于少菌型（18.38%）。结论：本研究通过原始病历核查、皮防人员调查、麻风病例随访的方法获得了麻风康复者家族史的准确信息。本研究中约1/5的麻风患者有家族史，提示我们应对麻风患者，尤其是多菌型麻风患者有血缘关系的亲属开展重点随访，延长随访时间，增加随访频次，以提高麻风的早期发现水平。

关键词: 麻风, 数据核查, 家族史, 流行病学分析

Abstract: Objective: To understand the family history data and annalyzed the epidemiological characteristics of leprosy patients with family history were mastered by more detailed investigation. Methods: A total of 2210 leprosy survivors were included. Family history and clinical information were obtained by of leprosy survivors by reviewing the original medical records and patient registration forms, investigating skin prevention workers and township doctors, and household follow-up. One-way t-test and chi-square test were performed by SPSS 25.0. Results: 1964 leprosy survivors was actually included in the analysis. The sex ratio of male to female was 3.9∶1, the mean age of onset was 22.18±12.14 years old, the mean age of diagnosis was 25.64±11.89 years old. The mainly type was tuberculoid leprosy （1026, 52.24%）and lepromatous leprosy（725, 36.91%）. There were 399 cases (20.32%)with a family history. The proportion of female（24.44%）leprosy patients with family history was higher than that of male（19.26%）. The proportion of Multibacillary (MB)（27.77%）leprosy patients with family history was higher than Paucibacillary (PB)（18.38%） patients. Conclusion:In this study, accurate information on the family history of leprosy survivors was obtained by the verification of original medical records, investigation of skin prevention workers and follow-up of leprosy cases. About one fifth of the leprosy patients have the family history, which suggests that we should carry out the key follow-up of the related relatives of leprosy patients especially multibacillary, including extending the follow-up time and increasing the frequency of follow-up, so as to improve the early detection level of leprosy.

Key words: leprosy, data verification, family history, epidemiological analysis