中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (8): 571-575.doi: 10.12144/zgmfskin202308571

• 论著 • 上一篇    下一篇

卡马西平致HLA-A*31:01基因携带者发生超敏反应综合征一例

刘佳怡1,2,赵晴2,吴卫志2,臧箫2,王伟伟2,孙乐乐2,周桂芝2,杨青2,刘红2,张福仁1，2   

  1. 1山东大学，济南，250012；2山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2023-08-15 发布日期:2023-07-19

Carbamazepine-induced DRESS syndrome with HLA-A*31:01 gene positive

LIU Jiayi1，2, ZHAO Qing2, WU Weizhi2, ZANG Xiao2, WANG Weiwei2, SUN Lele2, ZHOU Guizhi2, YANG Qing2, LIU Hong2, ZHANG Furen1,2   

  1. 1 Shandong University, Jinan 250012, China; 2 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-08-15 Published:2023-07-19

PDF (PC)

83

摘要： 目的：明确一例可能由卡马西平诱发的药物超敏反应综合征的诊断，确定致敏药物。方法：收集患者临床资料，提取患者外周血单个核细胞，进行HLA等位基因分型和淋巴细胞转化实验（lymphocyte transformation test, LTT）。结果：该患者HLA等位基因分型提示患者携带HLA-A*31:01；LTT结果显示在卡马西平刺激后，淋巴细胞进行增殖。结论：结合患者临床表现、HLA分型和LTT结果，诊断为由卡马西平诱发的药物超敏反应综合征。

关键词: 药物超敏反应综合征, 卡马西平, HLA-A*31:01

Abstract: Objective: To clarify the diagnosis and identify sensitizing drugs in a patients with eosinophilia and systemic symptoms (DRESS) syndromedrug hypersensitivity syndrome possibly induced by carbamazepine. Methods: Clinical data and the peripheral blood of the patient were collected and the peripheral blood mononuclear cells (PBMCs) were extracted. HLA testing and lymphocyte transformation test (LTT) were performed. Results: The HLA testing indicated that the patient carried the HLA-A*31:01 allele. The LTT results of this patient showed that lymphocytes proliferated after carbamazepine stimulation. Conclusion: Based on the clinical manifestations, HLA testing and LTT results, the patient was diagnosed as the DRESS syndrome induced by carbamazepine.

Key words: DRESS, carbamazepine, HLA-A*31:01