中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (11): 822-825.doi: 10.12144/zgmfskin202311822

• 病例报告 • 上一篇    下一篇

芦可替尼联合羟基脲治疗原发性血小板增多症引起多发性皮肤结核一例

郭丹丹,钱佳燕,黄子慧   

  1. 南京中医药大学附属南京市中西医结合医院，江苏南京，210014
  • 出版日期:2023-11-15 发布日期:2023-10-27

Multiple cutaneous tuberculosis caused by ruxolitinib and hydroxyurea treating for essential thrombocythemia: a case report

GUO Dandan, QIAN Jiayan, HUANG Zihui   

  1. Nanjing Municipal Hospital of Traditional Chinese and Western Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing 210014, China
  • Online:2023-11-15 Published:2023-10-27

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摘要： 本文报道一例脾脏切除后原发性血小板增多症患者，服用羟基脲及芦可替尼后诱发结核，抗结核治疗后好转，后出现腰腹部、手臂、大腿处多发性结核性皮肤溃疡，经局部处理（脓肿切开引流+清创+VSD负压吸引术/缝合术/局部换药）后痊愈。目前继续服用羟基脲及芦可替尼，未发生不良反应。

关键词: 原发性血小板增多症, 芦可替尼, 羟基脲, 结核性皮肤溃疡

Abstract: We report a case of essential thrombocythemia after splenectomy. Tuberculosis was induced by taking hydroxyurea and ruxolitinib, which was improved after anti-tuberculosis treatment. Then multiple tuberculous skin ulcers occurred in the waist, abdomen, arms and thighs, which were cured after local treatment (abscess incision and drainage and debridement and VSD negative pressure suction/suture/local dressing change). Hydroxyurea and ruxolitinib were continued to take at present, and no adverse reactions occurred.

Key words: essential thrombocytosis, ruxolitinib, hydroxyurea, tuberculous skin ulcer