中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (10): 730-733.doi: 10.12144/zgmfskin202410730

• 病例报告 • 上一篇    下一篇

注射抗CD20单克隆抗体后发生荨麻疹性血管炎一例

曹园园1,2*,张朝霞1,2*,刘永霞1,2,杨宝琦1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022 *共同第一作者
  • 出版日期:2024-10-15 发布日期:2024-08-28

Urticarial vasculitis after injection of anti-CD20 monoclonal antibody: a case report

CAO Yuanyuan1,2*, ZHANG Zhaoxia1,2*, LIU Yongxia1,2, YANG Baoqi1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China * Co-first author
  • Online:2024-10-15 Published:2024-08-28

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摘要： 患者，女，61岁。全身皮肤泛发红斑1天。起病前7天因“红斑型天疱疮”应用抗CD20单克隆抗体治疗。用药后躯干、四肢泛发水肿性红斑。结合组织病理诊断为荨麻疹性血管炎。给予甲泼尼龙、氯雷他定等治疗，4天后患者皮疹逐渐消退，原有红斑部位可见色素沉着斑。随访8个月，皮疹未复发。

关键词: 抗CD20单克隆抗体, 荨麻疹性血管炎

Abstract: A 61-year-old female presented with erythema all over the body for 1 day. The patient was treated with anti-CD20 monoclonal antibody for “pemphigus erythematosus” 7 days ago. Clinical manifestations combined with pathology, the diagnosis of urticarial vasculitis was made. The patient was treated with methylprednisolone and loratadine, and the rash gradually subsided after 4 days. Pigmentation spots were seen in the original erythema. The patient was followed up for 8 months, and the rash did not recur.

Key words: anti-CD20 monoclonal antibody, urticarial vasculitis