中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (3): 202-203.doi: 10.12144/zgmfskin202503202

• 病例报告 • 上一篇    下一篇

度普利尤单抗治疗嗜酸性脓疱性毛囊炎一例

孙艳红1,2,赵晴1,2,周隽3,张福仁1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022；3 复旦大学附属华山医院皮肤科，上海，200040
  • 出版日期:2025-03-15 发布日期:2025-03-03

Successful treatment of eosinophilic pustular folliculitis with dupilumab: a case report

SUN Yanhong1,2, ZHAO Qing1,2, ZHOU Jun3, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China; 3 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2025-03-15 Published:2025-03-03

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摘要： 本文中度普利尤单抗成功治疗嗜酸性脓疱性毛囊炎为国内首报，国外仅报道一例。患者，男，33岁。前胸、后背皮肤毛囊性丘疹8年，延及面部伴瘙痒2个月，结合实验室检查及病理检查，诊断为嗜酸性脓疱性毛囊炎。曾经多种药物口服及外用治疗效果不佳，给予患者度普利尤单抗治疗，3天后皮损开始逐渐改善，8周后，面部、胸背部皮损基本消退，留有色素沉着。

关键词: 嗜酸性脓疱性毛囊炎, 度普利尤单抗

Abstract: This is the first report in China on the successful treatment of eosinophilic pustular folliculitis with dupilumab, and only one case has been reported abroad. A 33-year-old man presented with eruption on the trunk for 8 years, and similar lesions with exudation on the face for 2 months. According to the laboratory examination and pathological examination, the diagnosis of eosinophilic pustular folliculitis was made. Dupilumab was given to the patient because of poor response to a variety of oral and topical drugs. After 3 days of dupilumab treatment, the skin lesions began to improve gradually, and eight weeks later, the skin lesions on the face, chest and back basically subsided, with pigmentation remaining.

Key words: eosinophilic pustular folliculitis, dupilumab