中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (6): 442-444.doi: 10.12144/zgmfskin202506442

• 病例报告 • 上一篇    下一篇

上眼睑结节性筋膜炎一例

骆万婷1，2,石翠萍1，2,程绍航1，2,阳芳1，2   

  1. 1 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院皮肤科，广东深圳，518020； 2 国家皮肤与免疫疾病临床医学研究中心分中心建设单位，广东深圳，518020
  • 出版日期:2025-06-15 发布日期:2025-05-23

Nodular fasciitis of the upper eyelid: a case report

LUO Wanting1,2, SHI Cuiping1,2, CHENG Shaohang1,2, YANG Fang1,2   

  1. 1 Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China; 2 Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen 518020, China
  • Online:2025-06-15 Published:2025-05-23

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摘要： 患者，女，32岁。左上睑皮下结节1个月。皮损组织病理示：真皮及皮下组织纤维组织增生，大量梭形细胞呈束状排列，细胞之间可见小裂隙，间质黏液样变，伴有淋巴细胞浸润和红细胞渗出。免疫组化示：Vimentin（+）、SMA（+），Ki-67约10%（+），Desmin（-）、CD34（-）、EMA（-）、CK（-）、S100（-）。皮损基因检测（FISH法）：检出USP6基因易位。诊断：结节性筋膜炎。手术切除术后随访1年无复发。

关键词: 结节性筋膜炎, USP6基因

Abstract: A 32-year-old female presented with a subcutaneous nodule on the left upper eyelid for one month. Histopathological examination showed fibroblastic proliferation in the dermis and subcutaneous tissue, with a large number of spindle cells arranged in bundles, small clefts visible between the cells, interstitial mucous-like changes, lymphocyte infiltration, and erythrocyte exudation. Immunohistochemical staining showed Vimentin and SMA（+）was positive, Ki-67 proliferation index was 10%, Desmin, CD34, EMA, CK, S100 were negitive. Genetic testing of the lesion (FISH method) detected a USP6 gene translocation. The diagnosis of nodular fasciitis was made. There was no recurrence after one year follow-up.

Key words: nodular fasciitis, USP6 gene