中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (8): 587-592.doi: 10.12144/zgmfskin202508587

• 临床研究 • 上一篇    下一篇

CO2点阵激光预处理后呋塞米和地高辛混合乳膏治疗皮肤疣疗效评价

李蜜,杨永斐,徐澄,徐灵亚,蒋进   

  1. 溧阳市人民医院皮肤科，江苏溧阳，213300
  • 出版日期:2025-08-15 发布日期:2025-07-31

Efficacy of furosemide and digoxin mixed cream in the treatment of cutaneous warts afer CO2 fractional laser pretreatment

LI Mi, YANG Yongfei, XU Cheng, XU Lingya, JIANG Jin   

  1. Department of Dermatology, Liyang People's Hospital, Liyang 213300, China
  • Online:2025-08-15 Published:2025-07-31

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摘要： 目的：评价CO2点阵激光预处理后使用呋塞米和地高辛混合乳膏治疗皮肤疣的疗效与安全性。方法：2024年3~10月于我院就诊的皮肤疣患者随机分为冷冻组与试验组。所有患者接受 CO2点阵激光预处理后，冷冻组给予冷冻治疗，试验组给予呋塞米和地高辛混合乳膏外用。治疗和随访均8周，评估皮损直径、皮损清除率及不良反应。结果：30例皮肤疣患者中27例完成研究，冷冻组15例(41个疣体)，试验组12例(43个疣体)。试验组疣体的完全清除率为39.5%，显著高于冷冻组的26.8%（P＜0.05）。皮肤镜下试验组21个（48.8%），冷冻组11个（26.8%）疣体消失，差异有统计学意义（P＜0.05）。冷冻组13例（86.7%）出现疼痛，11例（73.3%）出现烧灼感，试验组各1例（8.3%），不良反应发生率具有显著差异（P＜0.05）。结论：局部外用呋塞米和地高辛混合乳膏联合CO2点阵激光治疗皮肤疣疗效显著，不良反应发生率低，优于传统冷冻疗法。

关键词: 地高辛, 呋塞米, 皮肤疣, CO2点阵激光

Abstract: Objective: To evaluate the efficacy and safety of furosemide and digoxin mixed cream in the treatment of cutaneous warts after CO2 fractional laser pretreatment. Methods: Patients with cutaneous warts who attended our hospital from March 2024 to October 2024 were enrolled. The patients were randomly divided into a cryotherapy group and an experimental group. All patients received CO2 fractional laser pretreatment, then the control group was given cryotherapy, and the experimental group was treated with topical furosemide and digoxin mixed cream. Both treatment and follow-up lasted for 8 weeks. The diameter of lesions, lesion clearance rate and adverse reactions were evaluated. Results: Among 30 patients with cutaneous warts, 27 completed the study, including 15 cases in the cryotherapy group (41 warts) and 12 cases in the experimental group (43 warts). The complete clearance rate of warts in the experimental group was 39.5%, which was significantly higher than 26.8% in the cryotherapy group (P＜0.05). Under dermoscopy, 21 warts (48.8%) disappeared in the experimental group and 11 warts (26.8%) disappeared in the cryotherapy group, with a statistically significant difference (P＜0.05). In the cryotherapy group, 13 cases (86.7%) had pain and 11 cases (73.3%) had burning sensation, while only 1 case (8.3%) in the experimental group had each of the above reactions. There was a significant difference in the incidence of adverse reactions (P＜0.05). Conclusions: Topical application of furosemide and digoxin mixed cream combined with CO2 fractional laser is effective in the treatment of cutaneous warts with a low incidence of adverse reactions, which is superior to traditional cryotherapy.

Key words: digoxin, furosemide, cutaneous warts, CO2 laser