中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (10): 744-747.doi: 10.12144/zgmfskin202510744

• 病例报告 • 上一篇    下一篇

变应性血管炎合并骨髓增生异常综合征一例

覃阳1,冯江龙2,张伟1,朱浥溦1,蔡灵龙1,张国卿1,陆洪光1   

  1. 1贵州医科大学附属皮肤病医院皮肤科，贵州贵阳，550004； 2贵州医科大学附属皮肤病医院病理科，贵州贵阳，550004
  • 出版日期:2025-10-15 发布日期:2025-09-29

Allergic vasculitis complicated with myelodysplastic syndrome: a case report

QIN Yang1, FENG Jianglong2, ZHANG Wei1, ZHU Yiwei1, Cai Linglong1, ZHANG Guoqing1, LU Hongguang1   

  1. 1 Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; 2 Department of Pathology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
  • Online:2025-10-15 Published:2025-09-29

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摘要： 骨髓增生异常综合征（myelodysplastic syndromes, MDS）除血液系统表现外，还可能会出现皮肤相关症状，中性粒细胞皮肤病在MDS患者中较为常见，合并皮肤血管炎较为少见，容易导致诊断延误，本文报道一例变应性血管炎合并骨髓增生异常综合征的患者。 患者,女，61岁，全身暗紫红斑伴疼痛3个月。右手臂皮损处行活检示白细胞碎裂性血管炎，血常规示三系减少，进一步完善骨髓穿刺活检特点符合骨髓增生异常综合征。给予醋酸泼尼松片30 mg每天一次,经治疗14天后皮疹明显消退；血液科进一步治疗骨髓增生异常综合征。

关键词: 变应性血管炎, 骨髓增生异常综合征

Abstract: In addition to hematological manifestations, myelodysplastic syndromes (MDS) may also present with skin-related symptoms. Neutrophilic dermatoses are relatively common in MDS patients, while concurrent cutaneous vasculitis is rare, which may easily lead to delayed diagnosis. This paper reports a case of a patient with allergic vasculitis complicated with myelodysplastic syndrome. A 61-year-old female patient presented with dark purple erythema all over the body accompanied by pain for 3 months. Biopsy of the skin lesion on the right arm showed leukocytoclastic vasculitis. Routine blood tests revealed pancytopenia. Further bone marrow aspiration and biopsy confirmed the diagnosis of myelodysplastic syndrome. The patient was given 30mg of prednisone acetate tablets once a day. After 14 days of treatment, the skin rash subsided significantly. The patient was then referred to the hematology department for further treatment of myelodysplastic syndrome.

Key words: allergic vasculitis, myelodysplastic syndromes