中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (12): 724-726.

• 短篇论著 • 上一篇    下一篇

中国汉族大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感无相关性

杜甜甜1，2，付希安1，孙勇虎1 ，于功奇1，王真真1，杨宝琦1，卢宪梅1，刘红1，张福仁1   

  1. 1.山东省皮肤病性病防治研究所，济南 ，250022 2.济南大学山东省医学科学院医学与生命科学学院，济南， 250002
  • 出版日期:2016-12-15 发布日期:2018-12-21
  • 通讯作者: 张福仁，E-mail:zhangfuren@hotmail.com

Lack of association between GLCCI1 variant and glucocorticoid sensitivity in Chinese patients with bullous diseases

DU Tiantian1,2, FU Xi’an1, SUN Yonghu1, YU Gongqi1, WANG Zhenzhen1, YANG Baoqi1, LU Xianmei1, LIU Hong1, ZHANG Furen1   

  1. l. Shandong Provincial Institute of Dermatology and Venerueology, Provincial Academy of Medical Science, Jinan 250022, China; 2. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, China
  • Online:2016-12-15 Published:2018-12-21
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 目的：应用基因分型技术分析中国汉族种群大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感的相关性。方法：将187例大疱性皮肤病患者根据控制病情所需糖皮质激素用量分为实验组(糖皮质激素量≤60 mg，n=129)与对照组(糖皮质激素量≥150 mg，n=58)，应用Taqman genotyping技术对研究对象进行位于GLCCI1基因的SNP rs37973基因分型，数据资料应用PLINK软件进行logistic回归分析。结果：未发现GLCCI1基因的SNP rs37973与中国汉族种群大疱性皮肤病中糖皮质激素不敏感存在显著相关性（P=0.7881, OR=1.062）。结论：GLCCI1变异体与中国汉族种群大疱性皮肤病糖皮质激素不敏感无显著相关。

关键词: GLCCI1, 糖皮质激素, 大疱性皮肤病

Abstract: Objective: To investigate the association between GLCCI1 gene and GC sensitivity in Chinese patients with bullous diseases. Methods：A total of 187 subjects were divided into GC-sensitive group (control dose ≤60 mg, n=129) and GC-insensitive group (control dose ≥150 mg, n=58). Single SNP (rs37973) was genotyped with TaqMan SNP Genotyping Assay Kit on the GeneAmp 7900 Sequence Detection System using specific TaqMan probes. The statistical analysis was performed using logistic regression in PLINK. Results: We failed to detect rs37973 variation in the patients with GC-insensitive bullous diseases (P=0.7881, odds ratio=1.062). Conclusion: There is no association between GLCCI1 and glucocorticoids sensitivity in Chinese patients with bullous diseases.

Key words: GLCCI1, glucocorticoids, bullous diseases