中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (7): 391-393.

• 论著 • 上一篇    下一篇

终末期氧化蛋白产物与狼疮性肾炎的相关性

谢震1, 陈源汉2，王有为1，万慧颖1，刘杨英1，周敏1   

  1. 1四川省医学科学院四川省人民医院皮肤病性病研究所，四川成都，610000 2广东省医学科学院广东省人民医院肾内科，广东广州，510080
  • 出版日期:2016-07-15 发布日期:2018-12-21
  • 通讯作者: 陈源汉，E-mail: johnchen76@126.com

Relationship between advanced oxidation protein products and lupus nephritis

XIE Zhen1, CHEN Yuanhan2, WANG Youwei1, LIU Yangying1, WAN Huiying1, ZHOU Min1   

  1. 1. Department of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital , Chengdu 610000, China; 2. Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
  • Online:2016-07-15 Published:2018-12-21
  • Contact: CHEN Yuanhan, E-mail: johnchen76@126.com

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摘要： 目的：明确终末期氧化蛋白产物（AOPP）与狼疮性肾炎（LN）的相关性。方法：检测56例LD患者和36例LD合并LN患者血清中AOPP水平并分析AOPP水平与LN之间的相关性。结果： LD+LN患者中AOPP为(105.6±28.5) μmol/L高于LD患者的(64.6±20.4)μmol/L。 LD+LN患者高AOPP者（>84.5μmol/L）者较低AOPP者ds-DNA和尿蛋白水平更高，eGFR和补体C3水平更低。多变量二分类Logistic回归模型中，AOPP水平升高是发生LN的独立危险因素，AOPP每增加10μmol/L，发生LN的危险增加24%（95%可信区间1.166-1.915）。结论：AOPP可能和LN发病有关，有可能作为早期预测LN的指标。

关键词: 终末期氧化蛋白产物, 狼疮性皮炎, 狼疮性肾炎

Abstract: Objectives：To determine the relationship between advanced oxidation protein products (AOPP) and lupus nephritis (LN). Methods：The level of AOPP in 36 patients with lupus dermatitis (LD) complicated with LN and 56 LD patients without LN were detected and the relationship between AOPP and LN was analyzed. Results：The level of AOPP in LD accompanied with LN patients was (105.6±28.5)μmol/L, which was higher than that in the patients with LD but without LN (64.6±20.4 μmol/L). The level of ds-DNA and urine?protein in the patients with high level AOPP (>84.5μmol/L) was higher than those in the patients with low level of AOPP, and the level of eGFR and complement C3 was lower than those in the patients with low level of AOPP . In multivariable logistic regression model, AOPP level was an independent risk factor for lupus nephritis and the renal risk would increase by 24%, as every 10 μmol/L of AOPP was increased (95%CI 1.166-1.915). Conclusion：AOPP is associated with the onset of LN and may be a potential biomarker for LN.

Key words: advanced oxidation protein products, lupus nephritis, lupus dermatitis