中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (7): 410-412.

• 论著 • 上一篇    下一篇

银屑病患者外周血Th17/Th22细胞的表达

郭晓兰1,李秀娟2,杨文彪1 ,黄芳仪1   

  1. 1 江门市中心医院皮肤科,广东江门，529030 2 江门市中心医院检验科,广东江门，529030
  • 出版日期:2016-07-15 发布日期:2018-12-28
  • 通讯作者: 杨文彪，E-mail: yangwenbiao@medmail.com.cn

Expression of Th17 and Th22 in patients with psoriasis vulgaris

GUO Xiaolan1, LI Xiujuan2, YANG Wenbiao1, HUANG Fangyi1   

  1. 1. Department of Dermatology, the Central Hospital of Jiangmen, Jiangmen 529030, China; 2. Department of Clinical Laboratory, the Central Hospital of Jiangmen, Jiangmen 529030, China
  • Online:2016-07-15 Published:2018-12-28
  • Contact: YANG Wenbiao, E-mail: yangwenbiao@medmail.com.cn

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摘要： 目的:检测寻常性银屑病(PV)患者外周血Th17、 Th22的水平及相关因子IL-17、IL-22 、IL-6的血清水平。方法: PASI评分评估患者病情，采用流式细胞术检测40例PV患者和30例健康对照者外周血Th17和Th22细胞，ELISA法检测血清中IL-17、IL-22和IL-6水平。结果: PV患者Th17细胞及Th22细胞，血清IL-17、IL-22及血清IL-6的水平明显高于健康对照组比较（P均<0.01），且与PASI呈正相关（P＜0.05）。结论:Th17和Th22可能参与银屑病的发病。

Abstract: Objective: To detect the level of Th17 and Th22 and the expression of related cytokines including IL-17, IL-22 and IL-6 in of the patients with psoriasis vulgaris. Methods: The disease severity was evaluated by PASI scores. The levels of peripheral blood Th17 and Th22 cells in 40 patients and 30 healthy controls were detected by flow cytometry. The levels of serum IL-17, IL-22 and IL-6 were detected by ELISA. Results: The levels of Th17, Th22, IL-17,IL-22 and IL-6 in the patients with psoriasis vulgaris were higher than those in healthy controls (P＜0.01) and were positively correlated with PASI scores (P＜0.05). Conclusions: Th17 and Th22 cells may be involved in the pathogenesis of psoriasis vulgaris.