角蛋白17,自身免疫环路,银屑病 ," /> 角蛋白17,自身免疫环路,银屑病 ,"/> keratin 17,autoimmune loop,psoriasis ,"/> <p class="MsoNormal"> <span>角蛋白</span>17<span>与银屑病</span>

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (1): 62-64.

• 综述 • 上一篇    

角蛋白17与银屑病

姚秋楠  魏志平   

  1. 徐州医学院附属医院,江苏徐州， 221004

  • 出版日期:2017-01-15 发布日期:2018-12-11
  • 通讯作者: 魏志平, E-mail: xzwzp1961@aliyun.com

Keratin 17 and psoriasis

YAO Qiunan, WEI Zhiping.   

  1. Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China

  • Online:2017-01-15 Published:2018-12-11
  • Contact: WEI Zhiping, E-mail: xzwzp1961@aliyun.com

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摘要：

角蛋白17作为一种细胞骨架蛋白，在银屑病患者皮损中过度表达，被认为是银屑病的一种特异性标志物。角蛋白17是一种自身抗原，携带某些和链球菌M6蛋白相似的表位。这些表位可以刺激自身反应性T细胞增殖，促进银屑病相关的细胞因子释放，继而进一步刺激角质形成细胞产生角蛋白17。研究表明角蛋白17/T细胞/细胞因子自身免疫环路可能参与银屑病的发病机制，角蛋白17有可能成为一种新的银屑病治疗靶点。

关键词: 角蛋白17')">

角蛋白17, 自身免疫环路, 银屑病

Abstract:

As a cytoskeletal protein, keratin17 (K17) is over-expressed in psoriatic lesional epidermis, and is considered to be a hallmark of psoriasis.K17 is an autoantigen with certain epitopes similar to M6 protein of streptococci. These epitopes can stimulate the proliferation of autoreactive T cells and promote the release of psoriasis-related cytokines which stimulate keratinocyte to induce K17. Some studies indicate that K17/T cells/cytokine autoimmune loops may be present in the pathogenesis of psoriasis. K17 may be an attractive target of the novel therapies in psoriasis.

Key words: keratin 17')">

keratin 17, autoimmune loop, psoriasis