中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (10): 627-630.

• 综述 • 上一篇    下一篇

药物超敏综合征的遗传易感性研究进展

赵珲1,2  杨宝琦2   

  1. 1济南大学-山东省医学科学院医学与生命科学学院，济南，250062
    2山东省医学科学院山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2017-10-15 发布日期:2018-12-10
  • 通讯作者: 杨宝琦，E-mail：baoqiyang@126.com

Update of genetic susceptibility of drug-induced hypersensitivity syndrome

ZHAO Hui1,2, YANG Baoqi2.   

  1. 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250062, China; 2. Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, 250022, China
  • Online:2017-10-15 Published:2018-12-10
  • Contact: YANG Baoqi. E-mail: baoqiyang@126.com

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摘要： 药物超敏综合征是一类严重的药物不良反应，患者有发热、皮肤损害、嗜酸粒细胞升高、淋巴结肿大及肝脏受累等，流行病学调查发现其死亡率高达10%~20%。近年来，研究发现药物超敏综合征的发生与个体的遗传易感性，尤其是某些人类白细胞抗原（HLA）等位基因有关。本文综述了卡马西平，别嘌呤醇，氨苯砜，阿巴卡韦及奈韦拉平所致药物超敏综合征的遗传易感性研究进展。

关键词: 药物超敏综合征, 遗传易感性, 药物不良反应

Abstract: Drug-induced hypersensitivity syndrome (DIHS) is a type of adverse drug reaction. Patients usually have fever, skin lesions, multiple enlarged lymph nodes, eosinophilia and liver damage. Epidemiological survey showed that the mortality rate was as high as 10% to 20%. Recent years, researches reported that the occurrence of DIHS was to be associated with some human leukocyte antigen (HLA) alleles. The update of genetic susceptibility of DIHS induced by carbamazepine, allopurinol, aminosulfone, arbaca and nevirapine is reviewed in this article.

Key words: drug-induced hypersensitivity syndrome, genetic susceptibility, adverse drug reaction