寻常型银屑病,脑源性神经营养因子,血管内皮细胞生长因子


," /> 寻常型银屑病,脑源性神经营养因子,血管内皮细胞生长因子


,"/> psoriasis vulgaris,brain-derived neurotropic factor,vascular endothelial growth factor ,"/> <p class="MsoNormal"> <span>银屑病患者血浆脑源性神经营养因子和</span>VEGF<span>的表达</span>

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (3): 140-141.

• 论著 • 上一篇    下一篇

银屑病患者血浆脑源性神经营养因子和VEGF的表达

谢军1  李东升2   

  1. 1广西玉林市皮肤病防治医院，537000

    2 武汉市第一医院皮肤科，430022

  • 出版日期:2017-03-15 发布日期:2018-12-14
  • 通讯作者: 谢军, E-mail: xiejun9614@sohu.com

Expression of brain-derived neurotrophic factor and VEGF in the plasma of the patients with psoriasis vulgaris

XIE Jun1, LI Dongsheng2 /font>2   

  1. 1.Yulin Dermatosis Hospital, Yulin 537000, Guangxi, China; 2. Department of Dermatology, the First Hospital of Wuhan, Wuhan 430022, Hubei, China

  • Online:2017-03-15 Published:2018-12-14
  • Contact: XIE Jun, E-mail: xiejun9614@sohu.com

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摘要：

目的：检测脑源性神经营养因子(BDNF)及血管内皮细胞生长因子(VEGF)在寻常型银屑病(PV)患者血浆中的表达。方法：采用酶联免疫吸附试验(ELISA)分别检测23例进行期PV和19例稳定期PV患者血浆中BDNF及VEGF的表达,并以16名健康志愿者作对照。结果：PV患者血浆中BDNF及VEGF的表达均明显高于正常人(P<0.01),进行期患者的表达高于稳定期患者(P<0.01); BDNF的表达与PASI评分呈正相关(P<0.01),VEGF的表达与PASI评分无明显相关性(P>0.05)。结论：BDNF与VEGF可能参与了寻常型银屑病的发病机制

关键词: 寻常型银屑病')">

寻常型银屑病, 脑源性神经营养因子,
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Abstract:

Objective: To detect the expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in the plasma of the patients with psoriasis vulgaris (PV). Methods: The plasma levels of BDNF and VEGF were measured by ELISA in the 42 patients (23 patients in active stage and 19 in stable stage) and 16 healthy controls. Results: The plasma levels of BDNF and VEGF were higher in the patients with PV than in healthy controls (P<0.01). The levels of BDNF and VEGF in the patients in active stage were higher than in the patients in stable stage (P<0.01). There was a positive correlation between the plasma level of BDNF and PASI (P<0.01) and there was no correlation between plasma level of VEGF and PASI (P>0.05). Conclusion: BDNF and VEGF may be involved in the pathogenesis of PV

Key words: psoriasis vulgaris')">

psoriasis vulgaris, brain-derived neurotropic factor, vascular endothelial growth factor