枸地氯雷他定；变应性接触性皮炎；干扰素γ,肿瘤坏死因子α,白介素4 ," /> 枸地氯雷他定；变应性接触性皮炎；干扰素γ,肿瘤坏死因子α,白介素4 ,"/> desloratadine citrate disodium,ACD,IFN-γ,TNF-α,IL-4 ,"/> <p class="MsoNormal"> <span>枸地氯雷他定对小鼠变应性接触性皮炎中</span>Th1/Th2<span>的影响</span>

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (3): 156-158.

• 论著 • 上一篇    下一篇

枸地氯雷他定对小鼠变应性接触性皮炎中Th1/Th2的影响

王玉  刘静  薛亚东  田静   

  1. 哈尔滨医科大学附属第一医院，哈尔滨,150001

  • 出版日期:2017-03-15 发布日期:2018-12-17
  • 通讯作者: 田静，E-mail: 953273917@qq.com

Effects of desloratadine citrate disodium on the Th1/Th2 in mice ACD mode

WANG Yu, LIU Jing, XUE Yadong, TIAN Jing   

  1. The First Affiliated Hospital of Haerbin Medical University, Haerbin 150001, China

  • Online:2017-03-15 Published:2018-12-17
  • Contact: TIAN Jing, E-mail: 953273917@qq.com

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摘要：

目的：明确枸地氯雷他定对变应性接触性皮炎(ACD)小鼠耳廓肿胀程度的抑制作用以及对Th1/Th2相关细胞因子水平的影响。方法：建立ACD小鼠模型，观察口服不同剂量(1 mg/kg，2 mg/kg，3 mg/kg，4 mg/kg)枸地氯雷他定对ACD小鼠耳廓肿胀的抑制作用(应先造模，后饲药物)，采用ELISA 法检测小鼠血清中IL-4、IFN-γ,TNF-α的水平。结果：口服各剂量枸地氯雷他定均能明显抑制ACD小鼠的耳廓肿胀程度， 且具有剂量依赖性。模型组血清IFN-γ,IL-4,TNF-α水平明显高于正常对照组(P<0.01)，药物干预后血清IFN-γ,IL-4,TNF-α水平呈剂量依赖性下降。结论：枸地氯雷他定可能通过调节Th1/Th2相关细胞因子IFN-γ,IL-4,TNF-α水平对ACD小鼠的治疗发挥作用

关键词: 枸地氯雷他定；变应性接触性皮炎；干扰素γ')">

枸地氯雷他定；变应性接触性皮炎；干扰素γ, 肿瘤坏死因子α, 白介素4

Abstract:

Objective: To determine the effects of desloratadine citrate disodium on the edema degree of ears and the cytokine expression of Th1/Th2 cell in murine allergic contact dermatitis (ACD). Methods: The animal model of allergic contact dermatitis was established and then the inhibition effect of desloratadine citrate disodium in different doses (1 mg/kg, 2 mg/kg, 3 mg/kg and 4 mg/kg) on edema degree of ACD was assessed and the expression levels of IFN-γ, TNF-α and IL-4 were detected by ELISA. Results: Desloratadine citrate disodium can reduce the edema degree of ears. The levels of IFN-γ, TNF-α and IL-4 in serum of ACD mice were higher than that in blank controls (P<0.01) and the levels of the three cytokines in serum were all decreased after interfered by desloratadine citrate disodium, with a dose-dependent. Conclusion: Desloratadine citrate disodium is effective in the treatment of allergic contact dermatitis, which may be through regulating the levels of IFN- γ, TNF- α and IL- 4

Key words: desloratadine citrate disodium')">

desloratadine citrate disodium, ACD, IFN-γ, TNF-α, IL-4