Mas相关G蛋白偶联受体在皮肤源性瘙痒中的研究进展

中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (1): 57-60.

Mas相关G蛋白偶联受体在皮肤源性瘙痒中的研究进展

邵亦心，唐慧，王朵勤，沈燕芸，朱奕锜，徐金华

复旦大学附属华山医院皮肤科，上海200040

出版日期:2018-01-15 发布日期:2018-12-05
基金资助:
国家自然科学基金青年项目（编号：81402603）

Update of Mas-related G protein-coupled receptors in pruriceptive itch

SHAO Yixin, TANG Hui, WANG Duoqin, SHEN Yanyun, ZHU Yiqi, XU Jinhua.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China

Online:2018-01-15 Published:2018-12-05

摘要/Abstract

摘要： Mas相关G蛋白偶联受体家族(Mas-related G protein-coupled receptors，Mrgprs)是一类新型G蛋白偶联受体家族(G protein-coupled receptors，GPCR)，特异性分布于外周感觉神经元和肥大细胞，在瘙痒、疼痛等躯体感觉中具有重要的生理意义，可能成为抗瘙痒药物开发的新靶点。本文综述了Mrgprs的分类、分布、在皮肤源性瘙痒发生机制中的作用、细胞内信号传导通路及其临床应用价值等方面的研究进展

关键词: Mrgprs, 皮肤源性瘙痒, 组胺非依赖性, 脊髓背根神经元

Abstract: Mas-related G protein-coupled receptors, a novel type of G protein-coupled receptors, are specifically expressed in peripheral sensory neurons and mast cells. Mrgprs play an important physiologic role in itch or pain and may be a new target for anti-itching drugs. This review summarizes the current knowledge on the classification, expression, function in pruriceptive itch, intracellular signaling pathways and therapeutic potential of Mrgprs.

Key words: Mrgprs, pruriceptiveitch, histamine-independent, DRG neurons

邵亦心, 唐慧, 王朵勤, 沈燕芸, 朱奕锜, 徐金华. Mas相关G蛋白偶联受体在皮肤源性瘙痒中的研究进展[J]. 中国麻风皮肤病杂志, 2018, 34(1): 57-60.

SHAO Yixin, TANG Hui, WANG Duoqin, SHEN Yanyun, ZHU Yiqi, XU Jinhua.. Update of Mas-related G protein-coupled receptors in pruriceptive itch[J]. China Journal of Leprosy and Skin Diseases, 2018, 34(1): 57-60.