中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (4): 246-249.

• 综述 • 上一篇    下一篇

生殖支原体耐药位点与治疗研究进展

李洋 苏晓红   

  1. 210042 南京,北京协和医学院 中国医学科学院皮肤病研究所
  • 出版日期:2018-04-15 发布日期:2018-12-07
  • 通讯作者: 苏晓红,Email: suxh@ncstdlc.org
  • 基金资助:
    基金项目:NIH国际合作项目(U19 AI084048)

Drug resistance loci in Mycoplasma Genitalium and treatment

LI Yang, SU Xiaohong   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  • Online:2018-04-15 Published:2018-12-07
  • Contact: Su Xiaohong, Email: suxh@ncstdlc.org

摘要: 生殖支原体是引起男性非淋菌性尿道炎的重要病原体之一,主要的治疗药物包括四环素类、大环内酯类、喹诺酮类。近年来诸多研究报道,该病原体对多西环素及阿奇霉素的耐药程度日趋严重,亦不断出现莫西沙星治疗失败的案例。本文对生殖支原体耐药位点突变情况及治疗研究进展进行了综述。

关键词: 生殖支原体, 多西环素, 阿奇霉素, 莫西沙星, 抗药性

Abstract: Mycoplasma genitalium (Mg) is widely recognized as one of the important pathogens and it may cause non-gonococcal urethritis in males. Tetracyclines, macrolides and quinolones are effective in the treatment of the disease. Many recent studies have shown that resistance to doxycycline and azithromycin in Mg is more serious, and there are more reports of treatment failure with moxifloxacin. The update of the drug resistance loci of Mg and treatment is reviewed in this paper.

Key words: Mycoplasma Genitalium, doxycycline, azithromycin, moxifloxacin, drug resistance