中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (7): 441-443，448.

• 综述 • 上一篇    下一篇

滤泡性辅助性T细胞及其相关的皮肤病

闫天萌1,2 左亚刚2   

  1. 1. 香港大学深圳医院；深圳，518053；2.中国医学科学院北京协和医学院北京协和医院皮肤科，北京，100730
  • 出版日期:2018-07-15 发布日期:2018-12-14
  • 通讯作者: 左亚刚, E-mila: zuoyagang@263.com

Follicular helper T cells and related dermatoses

YAN Tianmeng1,2, ZUO Yagang2   

  1. 1.Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053,China; 2. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100730，China
  • Online:2018-07-15 Published:2018-12-14
  • Contact: ZUO Yagang, E-mila: zuoyagang@263.com

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摘要： 滤泡性辅助性T细胞（Tfh细胞）是一种新发现的CD4+辅助性T细胞。Tfh细胞在B细胞的增殖分化及产生高亲和力抗体中具有重要作用，参入体液免疫,很多疾病的发病与Tfh细胞相关，如系统性红斑狼疮、干燥综合征、过敏性疾病等。本文针对Tfh细胞及其在皮肤病中的作用进行综述。

关键词: Tfh细胞, Bcl-6, CXCR5

Abstract: Follicular helper T cells (Tfh cells) are distinguished from other CD4+T helper cells (Th cells). Tfh cells play an important role in the proliferation and differentiation of B cells and humoral immunity. Tfh cells were reported to play crucial roles in the autoimmune diseases，such as systemic lupus erythematosus, sjogren’s syndrome, allergic diseases and so on. Tfh cells and related disease is reviewed in this article.

Key words: Tfh cell, Bcl-6, CXCR5