中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (9): 538-542.

• 论著 • 上一篇    下一篇

类脂质渐进性坏死2例附文献复习

葛改1 路鸥2 刘淑梅2 史冬梅2   

  1. 1.济宁医学院 山东 济宁 272001 2.济宁市第一人民医院皮肤科 山东 济宁 272001
  • 出版日期:2018-09-15 发布日期:2018-12-11
  • 通讯作者: 史冬梅,E-mail: shidongmei28@163.com

Necrobiosis lipoidica: two-case report and literatures review

GE Gai 1, LU Ou 2, LIU Shumei 2, SHI Dongmei 2   

  1. 1.JiNing Medical University, Jining 272001, Shangdong, China 2.Department of Dermatology, Jining NO. 1 People’s Hospital, Jining 272001, Shangdong, China
  • Online:2018-09-15 Published:2018-12-11
  • Contact: SHI Dongmei，E-mail: shidongmei28@163.com

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摘要： 报道2例类脂质渐进性坏死（NL）并对国内外相关文献进行复习。例1，女，12岁，双胫前棕黄色萎缩性斑块2年、破溃2个月，病理确诊为NL。患者1合并2型糖尿病、高脂血症、重度肥胖，给予胰岛素降糖、双嘧达莫片，0.1%他克莫司软膏外用、多磺酸粘多糖乳膏等，皮损逐渐好转。例2，女，50岁，左下肢硬性红斑4年、加重2年，病理确诊为NL。患者2合并2型糖尿病，给予雷公藤多苷片、多磺酸粘多糖乳膏等，皮损逐渐好转。

关键词: 类脂质渐进性坏死, 糖尿病

Abstract: Two patients with necrobiosis lipoidica (NL) were reported and related literatures were reviewed in this paper. Patient one was a 12-years-old girl, who presented with brown yellow atrophic plaques on lower extremities for 2 years and ulcerated for 2 months. The biopsy features suggested NL. The patient was accompanied with type 2 diabetes, hyperlipidemia and severe obesity. The lesions subsided gradually after treated with insulin, dipyridamole tablets, topical tacrolimus ointment and mucopolysaccharide polysulfonate cream. Patient two was a 50-years-old female, who presented with, erythema on left shin for more than 4 years, aggravated for 2 years. This patient was also accompanied with type 2 diabetes and the biopsy features were also in accordance with NL. The lesions subsided gradually after treated with tripterygium and mucopolysaccharide polysulfonate cream.

Key words: necrobiosis lipoidica, diabetes mellitus

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