中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (3): 165-167.doi: 10.12144/zgmfskin202003165

• 短篇论著 • 上一篇    下一篇

成人种痘样水疱病样淋巴瘤一例并文献复习

杨佼,徐晨琛,崔炳南   

  1. 中国中医科学院广安门医院皮肤科，北京，100053
  • 出版日期:2020-03-15 发布日期:2020-03-30
  • 通讯作者: 徐晨琛，E-mail：xuchenchen86@foxmail.com

Adult hydroa vacciniforme-like lymphoma: a case report and literature review

YANG Jiao, XU Chenchen, CUI Bingnan   

  1. Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Online:2020-03-15 Published:2020-03-30
  • Contact: XU Chenchen, E-mail: xuchenchen86@foxmail.com

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摘要： 本文报道1例种痘样水疱病样淋巴瘤并对WHO最新分类、EBV感染相关发病机制、鉴别诊断及治疗方面的相关文献进行复习。患者，男，38岁。全身反复皮疹30年，加重1年，患者病程中伴有发热，皮损预后遗留凹陷性瘢痕。血清EB病毒抗体IgG阳性。皮损组织病理示：真皮全层及皮下脂肪小叶内大量淋巴细胞浸润。免疫组化染色示：CD2(+++)，CD3(++)，CD8(++)，TIA-1(++)，CD56(少量+)，CD20(灶状+) ，Ki-67＞30%。EB病毒原位杂交：阳性。诊断：种痘样水疱病样淋巴瘤。

关键词: 种痘样水疱病样淋巴瘤, 种痘样水疱病样淋巴增生性疾病, EB病毒

Abstract: A case of hydroa vacciniforme-like lymphoma was reported and the literature of the latest WHO classification, EBV infection-related pathogenesis, differential diagnosis and treatment were reviewed. A 38-year-old male presented with relapsed generalized lesions and fever for 30 years and aggravated for 1 year. Pitted scars were left after lesions relieved. The patient was positive for EB antibodies (IgG). Histopathological examination showed dense infiltration of lymphocytes in the whole dermis and subcutaneous tissue. Immunohistochemistory showed CD2(+++), CD3(++), CD8(++), TIA-1(++), CD56(+), CD20(focal +) , Ki-67＞30%, EBER(+). The diagnosis of hydroa vacciniforme-like lymphoma was made.

Key words: hydroa vacciniforme-like lymphoma, hydroa vacciniforme-like lymphoproliferative disorder, Epstein-Barr virus