中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (1): 66-68.doi: 10.12144/zgmfskin202501066

• 病例报告 • 上一篇    下一篇

乌帕替尼治疗20甲营养不良一例

吴恺悦1,2，刘鑫洲1,2，陈学超1,2，周桂芝1,2，刘国艳1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2025-01-15 发布日期:2024-12-24

Upadacitinib for the treatment of twenty-nail dystrophy: a case report

WU Kaiyue1,2, LIU Xinzhou1,2, CHEN Xuechao1,2, ZHOU Guizhi1,2, LIU Guoyan1,2   

  1. 1 Hospital for Skin Diserses, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-01-15 Published:2024-12-24

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摘要： 20甲营养不良(twenty-nail dystrophy,TND)是一种病因不明的甲损害，累及所有指/趾甲，可能由遗传因素及免疫系统异常而诱发。本病目前尚缺乏标准的治疗方案，传统治疗往往起效慢，不良反应明显。本文报道JAK-STAT抑制剂乌帕替尼治疗TND有效一例，患者口服乌帕替尼片15 mg/d，6个月后甲全部新生，减量至15 mg/2d；治疗8个月后，所有甲基本恢复正常。

关键词: 20甲营养不良, 乌帕替尼, JAK抑制剂

Abstract: Twenty-nail dystrophy (TND) is a nail damage of undetermined etiology that affects all the nails. It may be caused by genetic factors and abnormalities of the immune system. There is a lack of standard treatment for this disease, and its traditional treatment often has a slow onset of effect and obvious adverse reactions. This article reports that the JAK-STAT inhibitor upadacitinib is effective in the treatment of TND. The patient was treated with upadacitinib tablets 15 mg daily, and after 6 months, the nails regeneration was observed, and the dose was reduced to 15 mg every other day. After 8 months of treatment, all nails returned to normal.

Key words: twenty-nail dystrophy, upadacitinib, JAK inhibitor