中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (4): 281-283.doi: 10.12144/zgmfskin202604281

• 病例报告 • 上一篇    下一篇

表现为眼睑肿胀及面部红斑的皮肤血管肉瘤一例

张琪1,孔庆涛2,桑红1,张晨2,于婉婉2,陈珍珍2,惠云2   

  1. 1南京医科大学金陵临床医学院，江苏南京,210002； 2南京大学医学院附属金陵医院，江苏南京,210002
  • 出版日期:2026-04-15 发布日期:2026-04-08

Cutaneous angiosarcoma presenting with facial erythema and eyelid edema: a case report

ZHANG Qi1, KONG Qingtao2, SANG Hong1, ZHANG Chen2, YU Wanwan2, CHEN Zhenzhen2, HUI Yun2   

  1. 1 Jinling Clinical Medical College, Nanjing Medical University, Nanjing 210002, China; 2 Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
  • Online:2026-04-15 Published:2026-04-08

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摘要： 本文报道一例表现为非典型症状的头面部皮肤血管肉瘤。患者，男，81岁。双侧眼睑进行性肿胀8个月、伴面部浸润性无痛性红斑6个月。3个月前于外院诊断为“牙周病、淋巴结炎”，经抗炎治疗及拔牙处理后，皮损无明显改善且对侧面部出现类似皮损。发病后6个月就诊于我院，组织病理及免疫组化确诊为皮肤高分化血管肉瘤。本病例提示头面部血管肉瘤可仅表现为眼睑肿胀和面部红斑，缺乏典型紫癜样皮损，极易误诊。临床对老年患者头面部无痛性红斑及进行性软组织肿胀且抗炎治疗无效时，应高度警惕，尽早行病理活检以明确诊断。

关键词: 血管肉瘤, 非典型表现, 面部红斑

Abstract: We report a case of cutaneous angiosarcoma of the head and face with atypical manifestations. An 81-year-old male patient presented with progressive swelling of the unilateral eyelid for 8 months and infiltrative, painless erythema on the face for 6 months. He was diagnosed with “periodontal disease and lymphadenitis” at another hospital 3 months prior. After anti-inflammatory treatment and tooth extraction, the skin lesions showed no obvious improvement, and similar lesions appeared on the contralateral face. He was admitted to our hospital 6 months after onset. Cutaneous well-differentiated angiosarcoma was diagnosed by histopathology and immunohistochemistry. This case indicates that angiosarcoma of the head and face may present only with eyelid swelling and facial erythema, lacking typical purpuric lesions, and is easily misdiagnosed. For elderly patients with painless erythema and progressive soft tissue swelling of the head and face that is unresponsive to anti-inflammatory therapy, high suspicion and early pathological biopsy are warranted for a definite diagnosis.

Key words: cutaneous angiosarcoma, atypical presentation, facial erythema